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Discontinued Product(±)-3-(3-Nitrobenzoyl)alanine hydrochloride (Cat. No. 0799) has been withdrawn from sale for commercial reasons.
The first potent and selective inhibitor of kynurenine-3-hydroxylase. Increases the concentration of kynurenic acid in vivo.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Carpendo et al (1994) Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities. Neuroscience 61 237 PMID: 7969905
Chiarugi and Moroni (1999) Quinolinic acid formation in immune-activated mice: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(-3-nitrophenyl)thiazol-2yl]-benzenesulfonamide. Neuropharmacology 38 1225 PMID: 10462134
Pellicciari et al (1994) Modulation of the kynurenine pathway in search for new neuroprotective agents. Synthesis and preliminary evaluation of (m-nitrobenzoyl)alanine, a potent inhibitor of kynurenine-3-hydroxylase. J.Med.Chem. 37 647 PMID: 8126705
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Keywords: (±)-3-(3-Nitrobenzoyl)alanine hydrochloride, (±)-3-(3-Nitrobenzoyl)alanine hydrochloride supplier, Non-selective, Ionotropic, Glutamate, 0799, Tocris Bioscience
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Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.