DL 175

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Cat.No. 7082 - DL 175 | C17H14ClNO2
Description: Potent and selective GPR84 agonist
Chemical Name: 3-(2-((4-Chloronaphthalen-1-yl)oxy)ethyl)pyridine 1-oxide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for DL 175

DL 175 is a potent and selective GPR84 biased agonist (EC50 = 33 nM). Exhibits no significant activity in a panel of 168 other GPCRs. Exhibits bias for G protein signaling pathways. Induces morphological changes in primary murine bone marrow-derived macrophages (BMDMs) in a cellular impedance assay, and promotes phagocytosis by M1 polarized U937 cells. Induces migration of primary human monocytes, but has no effect on macrophage chemotaxis.

Technical Data for DL 175

M. Wt 299.75
Formula C17H14ClNO2
Storage Store at -20°C
Purity ≥98% (HPLC)
Smiles ClC1=C(C=CC=C2)C2=C(OCCC3=C[N+]([O-])=CC=C3)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DL 175

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 29.98 100
ethanol 29.98 100

Preparing Stock Solutions for DL 175

The following data is based on the product molecular weight 299.75. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.34 mL 16.68 mL 33.36 mL
5 mM 0.67 mL 3.34 mL 6.67 mL
10 mM 0.33 mL 1.67 mL 3.34 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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References for DL 175

References are publications that support the biological activity of the product.

Lucy et al (2019) A biased agonist at immunometabolic receptor GPR84 causes distinct functional effects in macrophages. ACS Chem.Biol 14 2055 PMID: 31465201

If you know of a relevant reference for DL 175, please let us know.

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Keywords: DL 175, DL 175 supplier, DL175, GPR84, potent, selective, agonists, agonism, macrophages, monocytes, chemotaxis, phagocytosis, Free, Fatty, Acid, Receptors, 7082, Tocris Bioscience

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Literature in this Area

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