DL 175

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Cat.No. 7082 - DL 175 | C17H14ClNO2
Description: Potent and selective GPR84 agonist
Chemical Name: 3-(2-((4-Chloronaphthalen-1-yl)oxy)ethyl)pyridine 1-oxide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Potent and selective GPR84 biased agonist (EC50 = 33 nM). Exhibits no significant activity in a panel of 168 other GPCRs. Exhibits bias for G protein signaling pathways. Induces morphological changes in primary murine bone marrow-derived macrophages (BMDMs) in a cellular impedance assay, and promotes phagocytosis by M1 polarized U937 cells. Induces migration of primary human monocytes, but has no effect on macrophage chemotaxis.

Technical Data

M. Wt 299.75
Formula C17H14ClNO2
Storage Store at -20°C
Purity ≥98% (HPLC)
InChI Key FXOVKEUUTXBOJZ-UHFFFAOYSA-N
Smiles ClC1=C(C=CC=C2)C2=C(OCCC3=C[N+]([O-])=CC=C3)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.98 100
ethanol 29.98 100

Preparing Stock Solutions

The following data is based on the product molecular weight 299.75. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.34 mL 16.68 mL 33.36 mL
5 mM 0.67 mL 3.34 mL 6.67 mL
10 mM 0.33 mL 1.67 mL 3.34 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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References

References are publications that support the biological activity of the product.

Lucy et al (2019) A biased agonist at immunometabolic receptor GPR84 causes distinct functional effects in macrophages. ACS Chem.Biol 14 2055 PMID: 31465201


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Keywords: DL 175, DL 175 supplier, DL175, GPR84, potent, selective, agonists, agonism, macrophages, monocytes, chemotaxis, phagocytosis, Free, Fatty, Acid, Receptors, 7082, Tocris Bioscience

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