Diprenorphine

Pricing Availability Delivery Time Qty
Cat.No. 2965 - Diprenorphine | C26H35NO4 | CAS No. 14357-78-9
Description: Non-selective opioid antagonist
Chemical Name: 17-(Cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α,α-dimethyl-6,14-ethenomorphinan-7-methanol
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Non-selective opioid receptor antagonist (Ki values are 0.017, 0.072 and 0.23 nM for κ-, μ- and δ-opioid receptors).

Technical Data

M. Wt 425.56
Formula C26H35NO4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 14357-78-9
PubChem ID 443408
InChI Key OIJXLIIMXHRJJH-KNLIIKEYSA-N
Smiles OC1=CC=C3C2=C1O[C@@H]([C@]7(OC)[C@@H]([C@@](C)(O)C)C4)[C@]52[C@@]4(CC7)[C@H](N(CC6CC6)CC5)C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.51 20
ethanol 10.64 25

Preparing Stock Solutions

The following data is based on the product molecular weight 425.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.35 mL 11.75 mL 23.5 mL
5 mM 0.47 mL 2.35 mL 4.7 mL
10 mM 0.23 mL 1.17 mL 2.35 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Paterson et al (1983) Classification of opioid receptors. Br.Med.Bull. 39 31 PMID: 6301606

Raynor et al (1994) Pharmacological characterization of the cloned κ-, δ-, and μ-opioid receptors. Mol.Pharmacol. 45 330 PMID: 8114680

Iwasaki et al (1994) The effect of the nonselective opioid antagonist diprenorphine vasopressin secretion in the rat. Endocrinology 134 48 PMID: 8275962


If you know of a relevant reference for Diprenorphine, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Miscellaneous Opioid Antagonists

Keywords: Diprenorphine, supplier, Non-Selective, opioids, antagonists, Receptors, Miscellaneous/Non-selective, Opioids, Miscellaneous/Non-selective, Opioids, Tocris Bioscience

Citations for Diprenorphine

Citations are publications that use Tocris products.

Currently there are no citations for Diprenorphine. Do you know of a great paper that uses Diprenorphine from Tocris? If so please let us know.

Reviews for Diprenorphine

There are currently no reviews for this product. Be the first to review Diprenorphine and earn rewards!

Have you used Diprenorphine?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Peptides Involved in Appetite Modulation

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Addiction

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.