Diprenorphine

Pricing Availability Delivery Time Qty
Cat.No. 2965 - Diprenorphine | C26H35NO4 | CAS No. 14357-78-9
Description: Non-selective opioid antagonist
Chemical Name: 17-(Cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α,α-dimethyl-6,14-ethenomorphinan-7-methanol
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Non-selective opioid receptor antagonist (Ki values are 0.017, 0.072 and 0.23 nM for κ-, μ- and δ-opioid receptors).

Technical Data

M. Wt 425.56
Formula C26H35NO4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 14357-78-9
PubChem ID 443408
InChI Key OIJXLIIMXHRJJH-KNLIIKEYSA-N
Smiles OC1=CC=C3C2=C1O[C@@H]([C@]7(OC)[C@@H]([C@@](C)(O)C)C4)[C@]52[C@@]4(CC7)[C@H](N(CC6CC6)CC5)C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 10.64 25
DMSO 8.51 20

Preparing Stock Solutions

The following data is based on the product molecular weight 425.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.35 mL 11.75 mL 23.5 mL
5 mM 0.47 mL 2.35 mL 4.7 mL
10 mM 0.23 mL 1.17 mL 2.35 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Paterson et al (1983) Classification of opioid receptors. Br.Med.Bull. 39 31 PMID: 6301606

Raynor et al (1994) Pharmacological characterization of the cloned κ-, δ-, and μ-opioid receptors. Mol.Pharmacol. 45 330 PMID: 8114680

Iwasaki et al (1994) The effect of the nonselective opioid antagonist diprenorphine vasopressin secretion in the rat. Endocrinology 134 48 PMID: 8275962


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Keywords: Diprenorphine, Diprenorphine supplier, Non-Selective, opioids, antagonists, Receptors, Miscellaneous/Non-selective, Opioids, 2965, Tocris Bioscience

1 Citation for Diprenorphine

Citations are publications that use Tocris products. Selected citations for Diprenorphine include:

Gardner et al (2015) Separating myoblast differentiation from muscle cell fusion using IGF-I and the p38 MAP kinase inhibitor SB202190. Am J Physiol Cell Physiol 309 C491 PMID: 26246429


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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