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Biological Activity for Diprenorphine
Diprenorphine is a non-selective opioid receptor antagonist (Ki values are 0.017, 0.072 and 0.23 nM for κ-, μ- and δ-opioid receptors).
Technical Data for Diprenorphine
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Diprenorphine
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Diprenorphine
The following data is based on the product molecular weight 425.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||9.4 mL||47 mL||93.99 mL|
|1.25 mM||1.88 mL||9.4 mL||18.8 mL|
|2.5 mM||0.94 mL||4.7 mL||9.4 mL|
|12.5 mM||0.19 mL||0.94 mL||1.88 mL|
References for Diprenorphine
References are publications that support the biological activity of the product.
Paterson et al (1983) Classification of opioid receptors. Br.Med.Bull. 39 31 PMID: 6301606
Raynor et al (1994) Pharmacological characterization of the cloned κ-, δ-, and μ-opioid receptors. Mol.Pharmacol. 45 330 PMID: 8114680
Iwasaki et al (1994) The effect of the nonselective opioid antagonist diprenorphine vasopressin secretion in the rat. Endocrinology 134 48 PMID: 8275962
If you know of a relevant reference for Diprenorphine, please let us know.
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Keywords: Diprenorphine, Diprenorphine supplier, Non-Selective, opioids, antagonists, Receptors, Miscellaneous/Non-selective, Opioids, 2965, Tocris Bioscience
1 Citation for Diprenorphine
Citations are publications that use Tocris products. Selected citations for Diprenorphine include:
Gardner et al (2015) Separating myoblast differentiation from muscle cell fusion using IGF-I and the p38 MAP kinase inhibitor SB202190. Am J Physiol Cell Physiol 309 C491 PMID: 26246429
Do you know of a great paper that uses Diprenorphine from Tocris? Please let us know.
Reviews for Diprenorphine
Average Rating: 5 (Based on 1 Review.)
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.