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Cat.No. 2965 - Diprenorphine | C26H35NO4 | CAS No. 14357-78-9
Description: Non-selective opioid antagonist
Chemical Name: 17-(Cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α,α-dimethyl-6,14-ethenomorphinan-7-methanol
Purity: ≥99% (HPLC)
Citations (1)
Reviews (1)
Literature (5)

Biological Activity for Diprenorphine

Diprenorphine is a non-selective opioid receptor antagonist (Ki values are 0.017, 0.072 and 0.23 nM for κ-, μ- and δ-opioid receptors).

Technical Data for Diprenorphine

M. Wt 425.56
Formula C26H35NO4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 14357-78-9
PubChem ID 443408
Smiles OC1=CC=C3C2=C1O[C@@H]([C@]7(OC)[C@@H]([C@@](C)(O)C)C4)[C@]52[C@@]4(CC7)[C@H](N(CC6CC6)CC5)C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Diprenorphine

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 8.51 20
ethanol 10.64 25

Preparing Stock Solutions for Diprenorphine

The following data is based on the product molecular weight 425.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 9.4 mL 47 mL 93.99 mL
1.25 mM 1.88 mL 9.4 mL 18.8 mL
2.5 mM 0.94 mL 4.7 mL 9.4 mL
12.5 mM 0.19 mL 0.94 mL 1.88 mL

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Product Datasheets for Diprenorphine

Certificate of Analysis / Product Datasheet
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References for Diprenorphine

References are publications that support the biological activity of the product.

Paterson et al (1983) Classification of opioid receptors. Br.Med.Bull. 39 31 PMID: 6301606

Raynor et al (1994) Pharmacological characterization of the cloned κ-, δ-, and μ-opioid receptors. Mol.Pharmacol. 45 330 PMID: 8114680

Iwasaki et al (1994) The effect of the nonselective opioid antagonist diprenorphine vasopressin secretion in the rat. Endocrinology 134 48 PMID: 8275962

If you know of a relevant reference for Diprenorphine, please let us know.

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Keywords: Diprenorphine, Diprenorphine supplier, Non-Selective, opioids, antagonists, Receptors, Miscellaneous/Non-selective, Opioids, 2965, Tocris Bioscience

1 Citation for Diprenorphine

Citations are publications that use Tocris products. Selected citations for Diprenorphine include:

Gardner et al (2015) Separating myoblast differentiation from muscle cell fusion using IGF-I and the p38 MAP kinase inhibitor SB202190. Am J Physiol Cell Physiol 309 C491 PMID: 26246429

Do you know of a great paper that uses Diprenorphine from Tocris? Please let us know.

Reviews for Diprenorphine

Average Rating: 5 (Based on 1 Review.)

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Diprenorphine in binding experiment.
By Anonymous on 01/13/2020
Assay Type: In Vitro
Species: Human

Diprenorphine was use to displace radiolabeled-diprenorphine in an homologous radiobinding assay.

review image

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*Please note that Tocris will only send literature to established scientific business / institute addresses.


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