Decynium 22

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Cat.No. 4722 - Decynium 22 | C23H23IN2 | CAS No. 977-96-8
Description: PMAT inhibitor
Chemical Name: 1-Ethyl-2-[(1-ethyl-2(1H)-quinolinylidene)methyl]quinolinium iodide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of the plasma membrane monoamine transporter (PMAT) (Ki = 0.10 μM).

Technical Data

M. Wt 454.35
Formula C23H23IN2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 977-96-8
PubChem ID 101932
InChI Key GMYRVMSXMHEDTL-UHFFFAOYSA-M
Smiles CC[N+]2=C(/C=C3/N(CC)C(C=CC=C4)=C4C=C3)C=CC1=CC=CC=C12.[I-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.54 10

Preparing Stock Solutions

The following data is based on the product molecular weight 454.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.2 mL 11 mL 22.01 mL
5 mM 0.44 mL 2.2 mL 4.4 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Engel and Wang (2005) Interaction of organic cations with a newly identified plasma membrane monoamine transporter. Mol.Pharmacol. 68 1397 PMID: 16099839

Xia et al (2009) Podocyte-specific expression of organic cation transporter PMAT: implication in puromycin aminonucleoside nephrotoxicity. Am.J.Physiol.Renal Physiol. 296 F1307 PMID: 19357181


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Keywords: Decynium22 PMAT plasma membrane monoamine transporters inhibitors inhibits Nucleoside Transporters

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New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
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  • Nuclear Receptors
  • Transporters
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