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Inhibitor of the plasma membrane monoamine transporter (PMAT) (Ki = 0.10 μM).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 454.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||22.01 mL||110.05 mL||220.09 mL|
|0.5 mM||4.4 mL||22.01 mL||44.02 mL|
|1 mM||2.2 mL||11 mL||22.01 mL|
|5 mM||0.44 mL||2.2 mL||4.4 mL|
References are publications that support the biological activity of the product.
Engel and Wang (2005) Interaction of organic cations with a newly identified plasma membrane monoamine transporter. Mol.Pharmacol. 68 1397 PMID: 16099839
Xia et al (2009) Podocyte-specific expression of organic cation transporter PMAT: implication in puromycin aminonucleoside nephrotoxicity. Am.J.Physiol.Renal Physiol. 296 F1307 PMID: 19357181
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Keywords: Decynium 22, Decynium 22 supplier, Decynium22, PMAT, plasma, membrane, monoamine, transporters, inhibitors, inhibits, Nucleoside, Transporters, 4722, Tocris Bioscience
1 Citation for Decynium 22
Citations are publications that use Tocris products. Selected citations for Decynium 22 include:
He et al (2017) Downregulation of miR-7116-5p in microglia by MPP+ sensitizes TNF-α production to induce dopaminergic neuron damage. Glia 65 1251 PMID: 28543680
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Reviews for Decynium 22
Average Rating: 4 (Based on 1 Review.)
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Excellent for blocking organic cation transport at 1 uM in rat aorta. However also acts as non-competitive antagonist of alpha-1 adrenoceptors. This is evidenced by the fact it can block vasoconstrictor responses induced by the alpha-1 adrenoceptor agonist phenylephrine in a non-competitive manner.
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