Decynium 22

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Cat.No. 4722 - Decynium 22 | C23H23IN2 | CAS No. 977-96-8
Description: PMAT inhibitor
Chemical Name: 1-Ethyl-2-[(1-ethyl-2(1H)-quinolinylidene)methyl]quinolinium iodide
Purity: ≥98% (HPLC)
Citations (1)
Reviews (1)
Literature (1)

Biological Activity

Inhibitor of the plasma membrane monoamine transporter (PMAT) (Ki = 0.10 μM).

Technical Data

M. Wt 454.35
Formula C23H23IN2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 977-96-8
PubChem ID 101932
Smiles CC[N+]2=C(/C=C3/N(CC)C(C=CC=C4)=C4C=C3)C=CC1=CC=CC=C12.[I-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 4.54 10

Preparing Stock Solutions

The following data is based on the product molecular weight 454.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.01 mL 110.05 mL 220.09 mL
0.5 mM 4.4 mL 22.01 mL 44.02 mL
1 mM 2.2 mL 11 mL 22.01 mL
5 mM 0.44 mL 2.2 mL 4.4 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Engel and Wang (2005) Interaction of organic cations with a newly identified plasma membrane monoamine transporter. Mol.Pharmacol. 68 1397 PMID: 16099839

Xia et al (2009) Podocyte-specific expression of organic cation transporter PMAT: implication in puromycin aminonucleoside nephrotoxicity. Am.J.Physiol.Renal Physiol. 296 F1307 PMID: 19357181

If you know of a relevant reference for Decynium 22, please let us know.

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Keywords: Decynium 22, Decynium 22 supplier, Decynium22, PMAT, plasma, membrane, monoamine, transporters, inhibitors, inhibits, Nucleoside, Transporters, 4722, Tocris Bioscience

1 Citation for Decynium 22

Citations are publications that use Tocris products. Selected citations for Decynium 22 include:

He et al (2017) Downregulation of miR-7116-5p in microglia by MPP+ sensitizes TNF-α production to induce dopaminergic neuron damage. Glia 65 1251 PMID: 28543680

Do you know of a great paper that uses Decynium 22 from Tocris? Please let us know.

Reviews for Decynium 22

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Also a non-competitive alpha-1 adrenoceptor antagonist.
By Alex Voisey on 10/25/2020
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: Aorta

Excellent for blocking organic cation transport at 1 uM in rat aorta. However also acts as non-competitive antagonist of alpha-1 adrenoceptors. This is evidenced by the fact it can block vasoconstrictor responses induced by the alpha-1 adrenoceptor agonist phenylephrine in a non-competitive manner.

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Literature in this Area

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