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Description: Mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor
Chemical Name: Sodium dichloroacetate
Literature (2)

Biological Activity for DCA

DCA is an inhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK). Shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. Induces mitochondrial-dependent apoptosis and reverses the inhibition/downregulation of KV1.5 channels in cancer but not normal cells. Decreases tumor growth in vitro and in vivo.

Technical Data for DCA

M. Wt 150.92
Formula C2HCl2NaO2
Storage Desiccate at RT
CAS Number 2156-56-1
PubChem ID 517326
Smiles [Na+].[O-]C(=O)C(Cl)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DCA

Solvent Max Conc. mg/mL Max Conc. mM
water 15.09 100
DMSO 15.09 100

Preparing Stock Solutions for DCA

The following data is based on the product molecular weight 150.92. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.63 mL 33.13 mL 66.26 mL
5 mM 1.33 mL 6.63 mL 13.25 mL
10 mM 0.66 mL 3.31 mL 6.63 mL
50 mM 0.13 mL 0.66 mL 1.33 mL

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References for DCA

References are publications that support the biological activity of the product.

Bowker-kinley et al (1998) Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex. Biochem.J. 329 191 PMID: 9405293

Bonnet et al (2007) A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 11 37 PMID: 17222789

Stacpoole (1989) The pharmacology of dichloroacetate. Metabolism Clin.Exp. 38 1124

If you know of a relevant reference for DCA, please let us know.

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Keywords: DCA, DCA supplier, Mitochondrial, pyruvate, dehydrogenase, kinase, PDK, inhibitors, inhibits, Kinases, Other, 2755, Tocris Bioscience

Citations for DCA

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