DC 260126

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Description: FFA1 (GPR40) antagonist
Chemical Name: N-(4-Butylphenyl)-4-fluorobenzenesulfonamide
Purity: ≥98% (HPLC)

Biological Activity for DC 260126

DC 260126 is a free fatty acid receptor 1 (FFA1/GPR40) antagonist. Inhibits FFA-induced increases in intracellular Ca2+ levels and suppresses palmitic acid potentiated glucose-stimulated insulin secretion in Min6 pancreatic β cells in vitro. Decreases serum insulin levels, improves insulin sensitivity and reduces the number of apoptotic pancreatic β cells in obese diabetic (db/db) rats.

Compound Libraries for DC 260126

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Technical Data for DC 260126

M. Wt 307.38
Formula C16H18FNO2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 346692-04-4
PubChem ID 2843133
Smiles CCCCC(C=C2)=CC=C2NS(C1=CC=C(F)C=C1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DC 260126

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 30.74 100
ethanol 30.74 100

Preparing Stock Solutions for DC 260126

The following data is based on the product molecular weight 307.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.25 mL 16.27 mL 32.53 mL
5 mM 0.65 mL 3.25 mL 6.51 mL
10 mM 0.33 mL 1.63 mL 3.25 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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References for DC 260126

References are publications that support the biological activity of the product.

Zhang et al (2010) DC260126, a small-molecule antagonist of GPR40, improves Ins tolerance but not glucose tolerance in obese Zucker rats. Biomed.Pharmacother. 64 647 PMID: 20888730

Sun et al (2013) DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db mice. PLoS ONE 8 e66744 PMID: 23776696

Hu et al (2009) A novel class of antagonists for the FFAs receptor GPR40. Biochem.Biophys.Res.Comm. 390 557 PMID: 19818732

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