DC 260126

Pricing Availability   Qty

15% Off Limited-time Savings on Your Reagents, Assays, and Kits
Now through September 27th, you can save 15% on Bio-Techne reagents, assays, and kits (including Novus, Tocris, and R&D Systems). Use promotion code SAVE15 at checkout on orders over $1,000. See terms and conditions for offer details.

Cat.No. 5357 - DC 260126 | C16H18FNO2S | CAS No. 346692-04-4
Description: FFA1 (GPR40) antagonist
Chemical Name: N-(4-Butylphenyl)-4-fluorobenzenesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity for DC 260126

DC 260126 is a free fatty acid receptor 1 (FFA1/GPR40) antagonist. Inhibits FFA-induced increases in intracellular Ca2+ levels and suppresses palmitic acid potentiated glucose-stimulated insulin secretion in Min6 pancreatic β cells in vitro. Decreases serum insulin levels, improves insulin sensitivity and reduces the number of apoptotic pancreatic β cells in obese diabetic (db/db) rats.

Compound Libraries for DC 260126

DC 260126 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for DC 260126

M. Wt 307.38
Formula C16H18FNO2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 346692-04-4
PubChem ID 2843133
InChI Key CNGHPXKWPGIDSK-UHFFFAOYSA-N
Smiles CCCCC(C=C2)=CC=C2NS(C1=CC=C(F)C=C1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DC 260126

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.74 100
ethanol 30.74 100

Preparing Stock Solutions for DC 260126

The following data is based on the product molecular weight 307.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.25 mL 16.27 mL 32.53 mL
5 mM 0.65 mL 3.25 mL 6.51 mL
10 mM 0.33 mL 1.63 mL 3.25 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for DC 260126

References are publications that support the biological activity of the product.

Zhang et al (2010) DC260126, a small-molecule antagonist of GPR40, improves Ins tolerance but not glucose tolerance in obese Zucker rats. Biomed.Pharmacother. 64 647 PMID: 20888730

Sun et al (2013) DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db mice. PLoS ONE 8 e66744 PMID: 23776696

Hu et al (2009) A novel class of antagonists for the FFAs receptor GPR40. Biochem.Biophys.Res.Comm. 390 557 PMID: 19818732


If you know of a relevant reference for DC 260126, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Free Fatty Acid Receptor Antagonists

Keywords: DC 260126, DC 260126 supplier, DC260126, GPR40, free, fatty, acid, receptors, 1, FFA1, insulin, sensitivity, Free, Fatty, Acid, Receptors, 5357, Tocris Bioscience

Citations for DC 260126

Citations are publications that use Tocris products.

Currently there are no citations for DC 260126. Do you know of a great paper that uses DC 260126 from Tocris? Please let us know.

Reviews for DC 260126

There are currently no reviews for this product. Be the first to review DC 260126 and earn rewards!

Have you used DC 260126?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR Product Listing

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling