DC 260126

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Cat.No. 5357 - DC 260126 | C16H18FNO2S | CAS No. 346692-04-4
Description: FFA1 (GPR40) antagonist
Chemical Name: N-(4-Butylphenyl)-4-fluorobenzenesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Free fatty acid receptor 1 (FFA1/GPR40) antagonist. Inhibits FFA-induced increases in intracellular Ca2+ levels and suppresses palmitic acid potentiated glucose-stimulated insulin secretion in Min6 pancreatic β cells in vitro. Decreases serum insulin levels, improves insulin sensitivity and reduces the number of apoptotic pancreatic β cells in obese diabetic (db/db) rats.

Compound Libraries

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Technical Data

M. Wt 307.38
Formula C16H18FNO2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 346692-04-4
PubChem ID 2843133
InChI Key CNGHPXKWPGIDSK-UHFFFAOYSA-N
Smiles CCCCC(C=C2)=CC=C2NS(C1=CC=C(F)C=C1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.74 100
ethanol 30.74 100

Preparing Stock Solutions

The following data is based on the product molecular weight 307.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.25 mL 16.27 mL 32.53 mL
5 mM 0.65 mL 3.25 mL 6.51 mL
10 mM 0.33 mL 1.63 mL 3.25 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Zhang et al (2010) DC260126, a small-molecule antagonist of GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats. Biomed.Pharmacother. 64 647 PMID: 20888730

Sun et al (2013) DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db mice. PLoS ONE 8 e66744 PMID: 23776696

Hu et al (2009) A novel class of antagonists for the FFAs receptor GPR40. Biochem.Biophys.Res.Comm. 390 557 PMID: 19818732


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Keywords: DC 260126, supplier, DC260126, GPR40, free, fatty, acid, receptors, 1, FFA1, insulin, sensitivity, Free, Fatty, Acid, Receptors, Tocris Bioscience

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GPCR

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