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Dapansutrile is a NLRP3 inflammasome inhibitor that disrupts inflammasome formation. Reduces LPS/ATP-induced IL-1β secretion in human and mouse macrophages in vitro, without affecting TNFα levels. Reduces LPS-induced inflammation in vivo. Also reduces joint swelling and markers of inflammation in synovial fluid in a mouse model of acute arthritis. Displays cardioprotective effects in a mouse model of cardiac ischemic reperfusion injury.
OLT1177® is a registered trademark of Olatec Therapeutics LLC in the United States and other countries.
Dapansutrile is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 133.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||7.51 mL||37.55 mL||75.09 mL|
|5 mM||1.5 mL||7.51 mL||15.02 mL|
|10 mM||0.75 mL||3.75 mL||7.51 mL|
|50 mM||0.15 mL||0.75 mL||1.5 mL|
References are publications that support the biological activity of the product.
Marchetti et al (2018) OLT1177®, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation. Proc.Natl.Acad.Sci.USA. 115 E1530 PMID: 29378952
Marchetti et al (2018) NLRP3 inflammasome inhibitor OLT1177® suppresses joint inflammation in murine models of acute arthritis. Arthritis Res.Ther. 20 169 PMID: 30075804
Toldo et al (2019) The NLRP3 inflammasome inhibitor, OLT1177® (Dapansutrile), reduces infarct size and preserves contractile function after ischemia reperfusion injury in the mouse. J.Cardiovasc.Pharmacol. 73 215 PMID: 30747785
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Keywords: Dapansutrile, Dapansutrile supplier, dapansutrile, NLRP3, inflammasome, inhibitors, inhibits, cardioprotective, arthritis, reperfusion, anti, inflammatory, Inflammasomes, 6902, Tocris Bioscience
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