Dantrolene, sodium salt

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Cat.No. 0507 - Dantrolene, sodium salt | C14H9N4NaO5 | CAS No. 14663-23-1
Description: Ca2+ release inhibitor
Chemical Name: 1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolinedione sodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (9)
Reviews (1)

Biological Activity

Inhibits release of Ca2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR) channels. Displays selectivity for RYR1 and RYR3 over RYR2. Protective against the effects of a variety of conditions and agents, including excitatory amino acids. Skeletal muscle relaxant and neuroprotectant.

Technical Data

M. Wt 336.23
Formula C14H9N4NaO5
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 14663-23-1
PubChem ID 6604100
InChI Key KSRLIXGNPXAZHD-HAZZGOGXSA-M
Smiles O=C([N-]3)N(CC3=O)/N=C/C1=CC=C(C2=CC=C([N+]([O-])=O)C=C2)O1.[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.36 10

Preparing Stock Solutions

The following data is based on the product molecular weight 336.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.74 mL 148.71 mL 297.42 mL
0.5 mM 5.95 mL 29.74 mL 59.48 mL
1 mM 2.97 mL 14.87 mL 29.74 mL
5 mM 0.59 mL 2.97 mL 5.95 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Hotchkiss and Karl (1994) Dantrolene ameliorates the metabolic hallmarks of sepsis in rats and improves survival in a mouse model of endotoxemia. Proc.Natl.Acad.Sci.U.S.A. 91 3039 PMID: 8159702

O'Mara et al (1995) Dantrolene inhibits long-term depression and depotentiation of synaptic transmission in the rat dentate gyrus. Neuroscience 68 621 PMID: 8577362

Zhao et al (2001) Dantrolene inhibition of ryanodine receptor Ca2+ release channels. J.Biol.Chem. 276 13810 PMID: 11278295

Merck Index 12 2879


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Keywords: Dantrolene, sodium salt, Dantrolene, sodium salt supplier, Ca2+, release, inhibitors, inhibits, Calcium, Signaling, Signalling, Agents, General, ryanodine, receptors, ion, channels, Ryanodine, Receptors, 0507, Tocris Bioscience

9 Citations for Dantrolene, sodium salt

Citations are publications that use Tocris products. Selected citations for Dantrolene, sodium salt include:

Battefeld et al (2019) High-Frequency Microdomain Ca2+ Transients and Waves during Early Myelin Internode Remodeling. Cell Rep 26 182 PMID: 30605675

Wieland et al (2006) Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell L-type calcium channels. J Pharmacol Exp Ther 47 296 PMID: 16831218

Wang et al (2015) Role of Na+/Ca2+ exchanger in Ca2+ homeostasis in rat suprachiasmatic nucleus neurons. J Neurophysiol 113 2114 PMID: 25568156

Florea et al (2017) Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma. Oncotarget 8 22876 PMID: 28206967


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Dantrolene modulates synaptic function.
By Anonymous on 08/17/2019
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: Hippocampus

Dantrolene was used to test impact of Ca2+ efflux from internal stores on neurotransmitter vesicle release in living neurons. Dantrolene, being added to intracellular solution, suppressed release of synaptic vesicles. Figure: change of a neuron electrical capacitance in response to series of electrical stimuli. Increase of electrical capacitance reflects increased number of vesicles fusing with cell membrane.

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