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Cat.No. 4684 - Daminozide | C6H12N2O3 | CAS No. 1596-84-5
Description: Selective KDM2/7 inhibitor
Chemical Name: 1-(2,2-Dimethylhydrazide)butanedioic acid
Literature (3)

Biological Activity

Histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.55, 1.5 and 2.1 μM for PHF8, KDM2A and KDM7A respectively). Exhibits ≥ 60-fold selectivity for KDM2/7 demethylases over other histone demethylases and 2-oxoglurate oxygenases (IC50 > 100 μM).

Technical Data

M. Wt 160.17
Formula C6H12N2O3
Storage Store at RT
CAS Number 1596-84-5
PubChem ID 15331
Smiles O=C(NN(C)C)CCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 16.02 100
water 16.02 100

Preparing Stock Solutions

The following data is based on the product molecular weight 160.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.24 mL 31.22 mL 62.43 mL
5 mM 1.25 mL 6.24 mL 12.49 mL
10 mM 0.62 mL 3.12 mL 6.24 mL
50 mM 0.12 mL 0.62 mL 1.25 mL

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References are publications that support the biological activity of the product.

Rose et al (2012) Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J.Med.Chem. 55 6639 PMID: 22724510

If you know of a relevant reference for Daminozide, please let us know.

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Keywords: Daminozide, Daminozide supplier, jmjc, kdm2/7, kdm2a, kdm7a, phf8, histone, demethylases, inhibits, inhibitors, selective, epigenetics, Histone, Demethylases, 4684, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Daminozide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov

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