Daminozide

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Cat.No. 4684 - Daminozide | C6H12N2O3 | CAS No. 1596-84-5
Description: Selective KDM2/7 inhibitor
Chemical Name: 1-(2,2-Dimethylhydrazide)butanedioic acid
Datasheet
Citations
Literature

Biological Activity

Histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.55, 1.5 and 2.1 μM for PHF8, KDM2A and KDM7A respectively). Exhibits ≥ 60-fold selectivity for KDM2/7 demethylases over other histone demethylases and 2-oxoglurate oxygenases (IC50 > 100 μM).

Compound Libraries

Daminozide is also offered as part of the Tocriscreen Plus and Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 160.17
Formula C6H12N2O3
Storage Store at RT
CAS Number 1596-84-5
PubChem ID 15331
InChI Key NOQGZXFMHARMLW-UHFFFAOYSA-N
Smiles O=C(NN(C)C)CCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.02 100
ethanol 3.2 20
water 16.02 100

Preparing Stock Solutions

The following data is based on the product molecular weight 160.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.24 mL 31.22 mL 62.43 mL
5 mM 1.25 mL 6.24 mL 12.49 mL
10 mM 0.62 mL 3.12 mL 6.24 mL
50 mM 0.12 mL 0.62 mL 1.25 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Rose et al (2012) Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J.Med.Chem. 55 6639 PMID: 22724510


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Citations for Daminozide

Citations are publications that use Tocris products.

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Epigenetics

Epigenetics Research Bulletin

Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

  • Bromodomains
  • DNA Methyltransferases
  • Histone Deacetylases
  • Histone Demethylases
  • Histone Methyltransferases

Pathways for Daminozide

Protocols

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