Histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.55, 1.5 and 2.1 μM for PHF8, KDM2A and KDM7A respectively). Exhibits ≥ 60-fold selectivity for KDM2/7 demethylases over other histone demethylases and 2-oxoglurate oxygenases (IC50 > 100 μM).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 160.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||6.24 mL||31.22 mL||62.43 mL|
|5 mM||1.25 mL||6.24 mL||12.49 mL|
|10 mM||0.62 mL||3.12 mL||6.24 mL|
|50 mM||0.12 mL||0.62 mL||1.25 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Rose et al (2012) Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J.Med.Chem. 55 6639 PMID: 22724510
If you know of a relevant reference for Daminozide, please let us know.
View Related Products by Product Action
Keywords: Daminozide, supplier, jmjc, kdm2/7, kdm2a, kdm7a, phf8, histone, demethylases, inhibits, inhibitors, selective, epigenetics, Histone, Demethylases, Histone, Demethylases, Tocris Bioscience
Citations for Daminozide
Citations are publications that use Tocris products.
Currently there are no citations for Daminozide. Do you know of a great paper that uses Daminozide from Tocris? If so please let us know.
Literature in this Area
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Epigenetics Research Bulletin
Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:
- DNA Methyltransferases
- Histone Deacetylases
- Histone Demethylases
- Histone Methyltransferases