(D)-PPA 1

Pricing Availability   Qty
Cat.No. 6515 - (D)-PPA 1 | D-Asn-D-Tyr-D-Ser-D-Lys-D-Pro-D-Thr-D-Asp-D-Arg-D-Gln-D-Tyr-D-His-D-Phe | CAS No. 1620813-53-7
Description: PD-1/PD-L1 interaction inhibitor
Datasheet
Citations
Reviews
Literature

Biological Activity

PD-1/PD-L1 interaction inhibitor. Binds to PD-L1 (Kd = 0.51 μM). Inhibits interaction at 1 mg/mL in flow cytometry. Inhibits tumor growth and prolongs survival time of mice in vivo.

Technical Data

M. Wt 1555.67
Formula C70H98N20O21
Sequence NYSKPTDRQYHF

(Modifications: Asn-1 = D-Asn, Tyr-2 = D-Tyr, Ser-3 = D-Ser, Lys-4 = D-Lys, Pro-5 = D-Pro, Thr-6 = D-Thr, Asp-7 = D-Asp, Arg-8 = D-Arg, Gln-9 = D-Gln, Tyr-10 = D-Tyr, His-11 = D-His, Phe-12 = D-Phe)

Storage Store at -20°C
CAS Number 1620813-53-7
InChI Key ZEZZLZKHZPMELC-UQRJQIDXNA-N
Smiles [H]N[C@H](CC(N)=O)C(=O)N[C@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CO)C(=O)N[C@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CC1=CNC=N1)C(=O)N[C@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 2 mg/ml in water

References

References are publications that support the biological activity of the product.

Chang et al (2015) Blocking of the PD-1/PD-L1 interaction by a D-peptide antagonist for cancer immunotherapy. Angew Chem.Int.Ed.Engl. 54 11760 PMID: 26259671


If you know of a relevant reference for (D)-PPA 1, please let us know.

View Related Products by Product Action

View all Immune Checkpoint Inhibitors

Keywords: (D)-PPA 1, (D)-PPA 1 supplier, (D)-PPA1, PD-1, PD-L1, programmmed, cell, death, ligand, 1, immune, checkpoint, inhibitors, inhibits, PD1, PDL1, CD279, Other, Apoptosis, Immune, Checkpoints, 6515, Tocris Bioscience

Citations for (D)-PPA 1

Citations are publications that use Tocris products.

Currently there are no citations for (D)-PPA 1. Do you know of a great paper that uses (D)-PPA 1 from Tocris? Please let us know.

Reviews for (D)-PPA 1

There are currently no reviews for this product. Be the first to review (D)-PPA 1 and earn rewards!

Have you used (D)-PPA 1?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Cancer Metabolism

Cancer Metabolism Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the main targets for cancer metabolism researchers. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways. These distinct metabolic circuits could provide viable cancer therapeutic targets.

Foundations of Immuno-oncology

Foundations of Immuno-oncology eBook

In this eBook, we examine the complexity of the tumor microenvironment, explore technologies that are innovating basic and translational research, and strategies that are advancing immunotherapy into the clinic.

Topics covered:

  • Tumor Microenvironment
  • Immune Checkpoints
  • Therapeutic Monoclonal Antibodies
  • Small Molecules & Immuno-Oncology
  • Cell-based Therapeutics
  • Cytokines and Immunotherapy
  • Tools to Advance Your Immuno-Oncology Research