You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for (D)-PPA 1
(D)-PPA 1 is a PD-1/PD-L1 interaction inhibitor. Binds to PD-L1 (Kd = 0.51 μM). Inhibits interaction at 1 mg/mL in flow cytometry. Inhibits tumor growth and prolongs survival time of mice in vivo.
Technical Data for (D)-PPA 1
(Modifications: Asn-1 = D-Asn, Tyr-2 = D-Tyr, Ser-3 = D-Ser, Lys-4 = D-Lys, Pro-5 = D-Pro, Thr-6 = D-Thr, Asp-7 = D-Asp, Arg-8 = D-Arg, Gln-9 = D-Gln, Tyr-10 = D-Tyr, His-11 = D-His, Phe-12 = D-Phe)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (D)-PPA 1
|Solubility||Soluble to 2 mg/ml in water|
References for (D)-PPA 1
References are publications that support the biological activity of the product.
Chang et al (2015) Blocking of the PD-1/PD-L1 interaction by a D-peptide antagonist for cancer immunotherapy. Angew Chem.Int.Ed.Engl. 54 11760 PMID: 26259671
If you know of a relevant reference for (D)-PPA 1, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: (D)-PPA 1, (D)-PPA 1 supplier, (D)-PPA1, PD-1, PD-L1, programmmed, cell, death, ligand, 1, immune, checkpoint, inhibitors, inhibits, PD1, PDL1, CD279, Other, Apoptosis, Immune, Checkpoints, 6515, Tocris Bioscience
Citations for (D)-PPA 1
Citations are publications that use Tocris products.
Currently there are no citations for (D)-PPA 1. Do you know of a great paper that uses (D)-PPA 1 from Tocris? Please let us know.
Reviews for (D)-PPA 1
There are currently no reviews for this product. Be the first to review (D)-PPA 1 and earn rewards!
Have you used (D)-PPA 1?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Metabolism Poster
Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the main targets for cancer metabolism researchers. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways. These distinct metabolic circuits could provide viable cancer therapeutic targets.
Foundations of Immuno-oncology eBook
This eBook examines the complexity of the tumor microenvironment, explores innovative technologies for basic and translational research, and strategies that are advancing immunotherapy into the clinic.
- Tumor Microenvironment
- Immune Checkpoints
- Therapeutic Monoclonal Antibodies
- Small Molecules & Immuno-Oncology
- Cell-based Therapeutics
- Cytokines and Immunotherapy
- Tools to Advance Your Immuno-Oncology Research