PD-1/PD-L1 interaction inhibitor. Binds to PD-L1 (Kd = 0.51 μM). Inhibits interaction at 1 mg/mL in flow cytometry. Inhibits tumor growth and prolongs survival time of mice in vivo.
(Modifications: Asn-1 = D-Asn, Tyr-2 = D-Tyr, Ser-3 = D-Ser, Lys-4 = D-Lys, Pro-5 = D-Pro, Thr-6 = D-Thr, Asp-7 = D-Asp, Arg-8 = D-Arg, Gln-9 = D-Gln, Tyr-10 = D-Tyr, His-11 = D-His, Phe-12 = D-Phe)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 2 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1555.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.64 mL||3.21 mL||6.43 mL|
|5 mM||0.13 mL||0.64 mL||1.29 mL|
|10 mM||0.06 mL||0.32 mL||0.64 mL|
|50 mM||0.01 mL||0.06 mL||0.13 mL|
References are publications that support the biological activity of the product.
Chang et al (2015) Blocking of the PD-1/PD-L1 interaction by a D-peptide antagonist for cancer immunotherapy. Angew Chem.Int.Ed.Engl. 54 11760 PMID: 26259671
If you know of a relevant reference for (D)-PPA 1, please let us know.
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