Home / Cell Biology / Signal Transduction / Immune Checkpoints / Immune Checkpoint Inhibitors / (D)-PPA 1

(D)-PPA 1

Cat. No. 6515 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Cat.No. 6515 - (D)-PPA 1 | D-Asn-D-Tyr-D-Ser-D-Lys-D-Pro-D-Thr-D-Asp-D-Arg-D-Gln-D-Tyr-D-His-D-Phe | CAS No. 1620813-53-7
Description: PD-1/PD-L1 interaction inhibitor
Datasheet
Citations
Reviews
Literature (4)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for (D)-PPA 1

(D)-PPA 1 is a PD-1/PD-L1 interaction inhibitor. Binds to PD-L1 (Kd = 0.51 μM). Inhibits interaction at 1 mg/mL in flow cytometry. Inhibits tumor growth and prolongs survival time of mice in vivo.

Technical Data for (D)-PPA 1

M. Wt 1555.67
Formula C70H98N20O21
Sequence NYSKPTDRQYHF

(Modifications: Asn-1 = D-Asn, Tyr-2 = D-Tyr, Ser-3 = D-Ser, Lys-4 = D-Lys, Pro-5 = D-Pro, Thr-6 = D-Thr, Asp-7 = D-Asp, Arg-8 = D-Arg, Gln-9 = D-Gln, Tyr-10 = D-Tyr, His-11 = D-His, Phe-12 = D-Phe)
Storage Store at -20°C
CAS Number 1620813-53-7
PubChem ID 134160249
InChI Key ZEZZLZKHZPMELC-SDQLLZIZSA-N
Smiles [H]N[C@H](CC(N)=O)C(=O)N[C@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CO)C(=O)N[C@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CC1=CNC=N1)C(=O)N[C@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (D)-PPA 1

Solubility Soluble to 2 mg/ml in water

Product Datasheets for (D)-PPA 1

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References for (D)-PPA 1

References are publications that support the biological activity of the product.

Chang et al (2015) Blocking of the PD-1/PD-L1 interaction by a D-peptide antagonist for cancer immunotherapy. Angew Chem.Int.Ed.Engl. 54 11760 PMID: 26259671

If you know of a relevant reference for (D)-PPA 1, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Immune Checkpoint Inhibitors

Keywords: (D)-PPA 1, (D)-PPA 1 supplier, (D)-PPA1, PD-1, PD-L1, programmmed, cell, death, ligand, 1, immune, checkpoint, inhibitors, inhibits, PD1, PDL1, CD279, Other, Apoptosis, Immune, Checkpoints, 6515, Tocris Bioscience

Citations for (D)-PPA 1

Citations are publications that use Tocris products.

Currently there are no citations for (D)-PPA 1. Do you know of a great paper that uses (D)-PPA 1 from Tocris? Please let us know.

Reviews for (D)-PPA 1

There are currently no reviews for this product. Be the first to review (D)-PPA 1 and earn rewards!

Have you used (D)-PPA 1?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology Product Listing

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Cancer Metabolism Poster

Cancer Metabolism Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the main targets for cancer metabolism researchers. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways. These distinct metabolic circuits could provide viable cancer therapeutic targets.

Foundations of Immuno-oncology eBook

Foundations of Immuno-oncology eBook

This eBook examines the complexity of the tumor microenvironment, explores innovative technologies for basic and translational research, and strategies that are advancing immunotherapy into the clinic.

Topics covered:

  • Tumor Microenvironment
  • Immune Checkpoints
  • Therapeutic Monoclonal Antibodies
  • Small Molecules & Immuno-Oncology
  • Cell-based Therapeutics
  • Cytokines and Immunotherapy
  • Tools to Advance Your Immuno-Oncology Research