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(D)-PPA 1

Cat. No. 6515 Submit a Review Datasheet / COA / SDS
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Cat.No. 6515 - (D)-PPA 1 | D-Asn-D-Tyr-D-Ser-D-Lys-D-Pro-D-Thr-D-Asp-D-Arg-D-Gln-D-Tyr-D-His-D-Phe | CAS No. 1620813-53-7
Description: PD-1/PD-L1 interaction inhibitor
Datasheet
Citations
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Literature (4)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for (D)-PPA 1

(D)-PPA 1 is a PD-1/PD-L1 interaction inhibitor. Binds to PD-L1 (Kd = 0.51 μM). Inhibits interaction at 1 mg/mL in flow cytometry. Inhibits tumor growth and prolongs survival time of mice in vivo.

Technical Data for (D)-PPA 1

M. Wt 1555.67
Formula C70H98N20O21
Sequence NYSKPTDRQYHF

(Modifications: Asn-1 = D-Asn, Tyr-2 = D-Tyr, Ser-3 = D-Ser, Lys-4 = D-Lys, Pro-5 = D-Pro, Thr-6 = D-Thr, Asp-7 = D-Asp, Arg-8 = D-Arg, Gln-9 = D-Gln, Tyr-10 = D-Tyr, His-11 = D-His, Phe-12 = D-Phe)
Storage Store at -20°C
CAS Number 1620813-53-7
PubChem ID 134160249
InChI Key ZEZZLZKHZPMELC-SDQLLZIZSA-N
Smiles [H]N[C@H](CC(N)=O)C(=O)N[C@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CO)C(=O)N[C@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CC1=CNC=N1)C(=O)N[C@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (D)-PPA 1

Solubility Soluble to 2 mg/ml in water

Product Datasheets for (D)-PPA 1

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References for (D)-PPA 1

References are publications that support the biological activity of the product.

Chang et al (2015) Blocking of the PD-1/PD-L1 interaction by a D-peptide antagonist for cancer immunotherapy. Angew Chem.Int.Ed.Engl. 54 11760 PMID: 26259671

If you know of a relevant reference for (D)-PPA 1, please let us know.

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Citations for (D)-PPA 1

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