(D)-PPA 1

Pricing Availability Delivery Time Qty
Cat.No. 6515 - (D)-PPA 1 | D-Asn-D-Tyr-D-Ser-D-Lys-D-Pro-D-Thr-D-Asp-D-Arg-D-Gln-D-Tyr-D-His-D-Phe | CAS No. 1620813-53-7
Description: PD-1/PD-L1 interaction inhibitor
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

PD-1/PD-L1 interaction inhibitor. Binds to PD-L1 (Kd = 0.51 μM). Inhibits interaction at 1 mg/mL in flow cytometry. Inhibits tumor growth and prolongs survival time of mice in vivo.

Technical Data

M. Wt 1555.67
Formula C70H98N20O21
Sequence NYSKPTDRQYHF

(Modifications: Asn-1 = D-Asn, Tyr-2 = D-Tyr, Ser-3 = D-Ser, Lys-4 = D-Lys, Pro-5 = D-Pro, Thr-6 = D-Thr, Asp-7 = D-Asp, Arg-8 = D-Arg, Gln-9 = D-Gln, Tyr-10 = D-Tyr, His-11 = D-His, Phe-12 = D-Phe)

Storage Store at -20°C
CAS Number 1620813-53-7
InChI Key ZEZZLZKHZPMELC-UQRJQIDXNA-N
Smiles [H]N[C@H](CC(N)=O)C(=O)N[C@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CO)C(=O)N[C@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CC1=CNC=N1)C(=O)N[C@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1555.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.64 mL 3.21 mL 6.43 mL
5 mM 0.13 mL 0.64 mL 1.29 mL
10 mM 0.06 mL 0.32 mL 0.64 mL
50 mM 0.01 mL 0.06 mL 0.13 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Chang et al (2015) Blocking of the PD-1/PD-L1 interaction by a D-peptide antagonist for cancer immunotherapy. Angew Chem.Int.Ed.Engl. 54 11760 PMID: 26259671


If you know of a relevant reference for (D)-PPA 1, please let us know.

View Related Products by Target

Keywords: (D)-PPA 1, supplier, (D)-PPA1, PD-1, PD-L1, programmmed, cell, death, ligand, 1, immune, checkpoint, inhibitors, inhibits, Other, Apoptosis, Other, Apoptosis, Tocris Bioscience

Citations for (D)-PPA 1

Citations are publications that use Tocris products.

Currently there are no citations for (D)-PPA 1. Do you know of a great paper that uses (D)-PPA 1 from Tocris? If so please let us know.

Reviews for (D)-PPA 1

There are currently no reviews for this product. Be the first to review (D)-PPA 1 and earn rewards!

Have you used (D)-PPA 1?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for (D)-PPA 1

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.