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Description: PD-1/PD-L1 interaction inhibitor
Purity: ≥95% (HPLC)
Biological Activity for (D)-PPA 1
(D)-PPA 1 is a PD-1/PD-L1 interaction inhibitor. Binds to PD-L1 (Kd = 0.51 μM). Inhibits interaction at 1 mg/mL in flow cytometry. Inhibits tumor growth and prolongs survival time of mice in vivo.
Technical Data for (D)-PPA 1
| M. Wt | 1555.67 |
| Formula | C70H98N20O21 |
| Sequence |
NYSKPTDRQYHF (Modifications: Asn-1 = D-Asn, Tyr-2 = D-Tyr, Ser-3 = D-Ser, Lys-4 = D-Lys, Pro-5 = D-Pro, Thr-6 = D-Thr, Asp-7 = D-Asp, Arg-8 = D-Arg, Gln-9 = D-Gln, Tyr-10 = D-Tyr, His-11 = D-His, Phe-12 = D-Phe) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 1620813-53-7 |
| PubChem ID | 134160249 |
| InChI Key | ZEZZLZKHZPMELC-SDQLLZIZSA-N |
| Smiles | [H]N[C@H](CC(N)=O)C(=O)N[C@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CO)C(=O)N[C@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CC1=CNC=N1)C(=O)N[C@H](CC1=CC=CC=C1)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (D)-PPA 1
| Solubility | Soluble to 2 mg/ml in water |
Product Datasheets for (D)-PPA 1
References for (D)-PPA 1
References are publications that support the biological activity of the product.
Chang et al (2015) Blocking of the PD-1/PD-L1 interaction by a D-peptide antagonist for cancer immunotherapy. Angew Chem.Int.Ed.Engl. 54 11760 PMID: 26259671
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Keywords: (D)-PPA 1, (D)-PPA 1 supplier, (D)-PPA1, PD-1, PD-L1, programmmed, cell, death, ligand, 1, immune, checkpoint, inhibitors, inhibits, PD1, PDL1, CD279, Other, Apoptosis, Immune, Checkpoints, 6515, Tocris Bioscience
1 Citation for (D)-PPA 1
Citations are publications that use Tocris products. Selected citations for (D)-PPA 1 include:
Qiang et al (2021) Tumor-associated neutrophils activated by tumor-derived CCL20 (C-C motif chemokine ligand 20) promote T cell immunosuppression via programmed death-ligand 1 (PD-L1) in breast cancer. Bioengineered 12 6996-7006 PMID: 34519637
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