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[D-Phe12,Leu14]-Bombesin

Cat. No. 3422 Submit a Review Datasheet / COA / SDS
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Cat.No. 3422 - [D-Phe12,Leu14]-Bombesin | Glp-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-D-Phe-Leu-Leu-NH2 | CAS No. 108437-88-3
Description: Bombesin receptor antagonist
Datasheet
Citations
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Literature (3)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for [D-Phe12,Leu14]-Bombesin

[D-Phe12,Leu14]-Bombesin is a bombesin receptor antagonist that inhibits bombesin binding to rat brain with an IC50 value of 2 μM. Inhibits amylase release in vitro (IC50 = 4 μM) and attenuates bombesin-mediated suppression of food intake in vivo.

Technical Data for [D-Phe12,Leu14]-Bombesin

M. Wt 1610.9
Formula C75H114N22O18
Sequence XQRLGNQWAVGFLL

(Modifications: X = Glp, Phe-12 = D-Phe, Leu-14 = C-terminal amide)
Storage Store at -20°C
CAS Number 108437-88-3
PubChem ID 16168803
InChI Key PWGHKRYOBBMXGB-TVXZQRGPSA-N
Smiles [H]N1[C@@H](CCC1=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for [D-Phe12,Leu14]-Bombesin

Solubility Soluble to 10 mg/ml in water

Product Datasheets for [D-Phe12,Leu14]-Bombesin

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for [D-Phe12,Leu14]-Bombesin

References are publications that support the biological activity of the product.

Heinz-Erian et al (1987) [d-Phe12]bombesin analogues: a new class of bombesin receptor antagonists. Am.J.Physiol. 252 G439 PMID: 2435173

Merali et al (1988) (d-Phe12) bombesin and substance P analogues function as central bombesin receptor antagonists. Synapse 2 282 PMID: 2463692

Flynn (1997) Bombesin receptor antagonists block the effects of exogenous bombesin but not of nutrients on food intake. Physiol.Behav. 62 791 PMID: 9284499

If you know of a relevant reference for [D-Phe12,Leu14]-Bombesin, please let us know.

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Citations for [D-Phe12,Leu14]-Bombesin

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