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Biological Activity for [D-Phe12,Leu14]-Bombesin
[D-Phe12,Leu14]-Bombesin is a bombesin receptor antagonist that inhibits bombesin binding to rat brain with an IC50 value of 2 μM. Inhibits amylase release in vitro (IC50 = 4 μM) and attenuates bombesin-mediated suppression of food intake in vivo.
Technical Data for [D-Phe12,Leu14]-Bombesin
(Modifications: X = Glp, Phe-12 = D-Phe, Leu-14 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for [D-Phe12,Leu14]-Bombesin
|Solubility||Soluble to 10 mg/ml in water|
Product Datasheets for [D-Phe12,Leu14]-Bombesin
References for [D-Phe12,Leu14]-Bombesin
References are publications that support the biological activity of the product.
Heinz-Erian et al (1987) [d-Phe12]bombesin analogues: a new class of bombesin receptor antagonists. Am.J.Physiol. 252 G439 PMID: 2435173
Merali et al (1988) (d-Phe12) bombesin and substance P analogues function as central bombesin receptor antagonists. Synapse 2 282 PMID: 2463692
Flynn (1997) Bombesin receptor antagonists block the effects of exogenous bombesin but not of nutrients on food intake. Physiol.Behav. 62 791 PMID: 9284499
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Citations for [D-Phe12,Leu14]-Bombesin
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.