[D-Phe12,Leu14]-Bombesin

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Cat.No. 3422 - [D-Phe12,Leu14]-Bombesin | Glp-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-D-Phe-Leu-Leu-NH2 | CAS No. 108437-88-3
Description: Bombesin receptor antagonist
Datasheet
Citations

Biological Activity

Bombesin receptor antagonist that inhibits bombesin binding to rat brain with an IC50 value of 2 μM. Inhibits amylase release in vitro (IC50 = 4 μM) and attenuates bombesin-mediated suppression of food intake in vivo.

Technical Data

M. Wt 1610.9
Formula C75H114N22O18
Sequence XQRLGNQWAVGFLL

(Modifications: X = Glp, Phe-12 = D-Phe, Leu-14 = C-terminal amide)

Storage Store at -20°C
CAS Number 08437-88-3
PubChem ID 16168803
InChI Key PWGHKRYOBBMXGB-TVXZQRGPSA-N
Smiles [H]N1[C@@H](CCC1=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 10 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1610.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.62 mL 3.1 mL 6.21 mL
5 mM 0.12 mL 0.62 mL 1.24 mL
10 mM 0.06 mL 0.31 mL 0.62 mL
50 mM 0.01 mL 0.06 mL 0.12 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Heinz-Erian et al (1987) [d-Phe12]bombesin analogues: a new class of bombesin receptor antagonists. Am.J.Physiol. 252 G439 PMID: 2435173

Merali et al (1988) (d-Phe12) bombesin and substance P analogues function as central bombesin receptor antagonists. Synapse 2 282 PMID: 2463692

Flynn (1997) Bombesin receptor antagonists block the effects of exogenous bombesin but not of nutrients on food intake. Physiol.Behav. 62 791 PMID: 9284499


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Keywords: Bombesin receptor antagonists GRP-Preferring Receptors BB1 BB2 BB3 Gastrin-Releasing Peptide-Preferring NMB-Preferring Neuromedin B-Preferring Bombesin Receptor Peptide

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