[D-Phe12,Leu14]-Bombesin
![Cat.No. 3422 - [D-Phe12,Leu14]-Bombesin | Glp-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-D-Phe-Leu-Leu-NH2 | CAS No. 108437-88-3](http://resources.tocris.com/images/datasheets/structures/d-phe12-leu14-bombesin_3422.png "Cat.No. 3422 - [D-Phe12,Leu14]-Bombesin | Glp-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-D-Phe-Leu-Leu-NH2 | CAS No. 108437-88-3")
Biological Activity
Bombesin receptor antagonist that inhibits bombesin binding to rat brain with an IC50 value of 2 μM. Inhibits amylase release in vitro (IC50 = 4 μM) and attenuates bombesin-mediated suppression of food intake in vivo.
Technical Data
| M. Wt | 1610.9 |
| Formula | C75H114N22O18 |
| Sequence |
XQRLGNQWAVGFLL (Modifications: X = Glp, Phe-12 = D-Phe, Leu-14 = C-terminal amide) |
| Storage | Store at -20°C |
| CAS Number | 08437-88-3 |
| PubChem ID | 16168803 |
| InChI Key | PWGHKRYOBBMXGB-TVXZQRGPSA-N |
| Smiles | [H]N1[C@@H](CCC1=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 10 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1610.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.62 mL | 3.1 mL | 6.21 mL |
| 5 mM | 0.12 mL | 0.62 mL | 1.24 mL |
| 10 mM | 0.06 mL | 0.31 mL | 0.62 mL |
| 50 mM | 0.01 mL | 0.06 mL | 0.12 mL |
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References
References are publications that support the products' biological activity.
Heinz-Erian et al (1987) [d-Phe12]bombesin analogues: a new class of bombesin receptor antagonists. Am.J.Physiol. 252 G439 PMID: 2435173
Merali et al (1988) (d-Phe12) bombesin and substance P analogues function as central bombesin receptor antagonists. Synapse 2 282 PMID: 2463692
Flynn (1997) Bombesin receptor antagonists block the effects of exogenous bombesin but not of nutrients on food intake. Physiol.Behav. 62 791 PMID: 9284499
If you know of a relevant reference for [D-Phe12,Leu14]-Bombesin, please let us know.
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Keywords: Bombesin receptor antagonists GRP-Preferring Receptors BB1 BB2 BB3 Gastrin-Releasing Peptide-Preferring NMB-Preferring Neuromedin B-Preferring Bombesin Receptor Peptide
Citations for [D-Phe12,Leu14]-Bombesin
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