Discontinued Product

[D-Phe12]-Bombesin (Cat. No. 1913) has been withdrawn from sale for commercial reasons.
Description: Bombesin receptor antagonist
Literature (1)

Biological Activity for [D-Phe12]-Bombesin

Bombesin receptor antagonist; inhibits bombesin-induced amylase release in guinea pig pancreas (IC50 = 4 mM). Centrally active in vivo.

Technical Data for [D-Phe12]-Bombesin

M. Wt 1629.9
Formula C74H112N22O18S

(Modifications: X = Glp, Phe-12 = D-Phe, Gly-14 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 108437-87-2
PubChem ID 57340149
Smiles [H]N1[C@@H](CCC1=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for [D-Phe12]-Bombesin

Certificate of Analysis / Product Datasheet
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References for [D-Phe12]-Bombesin

References are publications that support the biological activity of the product.

Heinz-Erian et al (1987) [D-Phe12]Bombesin analogues: a new class of bombesin receptor antagonists. Am.J.Physiol. 252 G439 PMID: 2435173

Merali et al (1988) (D-Phe12) Bombesin and substance P analogues function as central bombesin receptor antagonists. Synapse 2 282 PMID: 2463692

Moody et al (1988) Localization of receptors for bombesin-like peptides in the rat brain. Ann.N.Y.Acad.Sci. 547 114 PMID: 2853589

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Keywords: [D-Phe12]-Bombesin, [D-Phe12]-Bombesin supplier, Bombesin, receptor, antagonists, GRP-Preferring, Receptors, BB1-3, Gastrin-Releasing, Peptide-Preferring, NMB-Preferring, Neuromedin, B-Preferring, 1913, Tocris Bioscience

Citations for [D-Phe12]-Bombesin

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.