[D-Phe12]-Bombesin

Pricing Availability Delivery Time Qty
Cat.No. 1913 - [D-Phe12]-Bombesin | Glp-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-D-Phe-Leu-Met-NH2 | CAS No. 108437-87-2
Description: Bombesin receptor antagonist
Datasheet
Citations

Biological Activity

Bombesin receptor antagonist; inhibits bombesin-induced amylase release in guinea pig pancreas (IC50 = 4 mM). Centrally active in vivo.

Technical Data

M. Wt 1629.9
Formula C74H112N22O18S
Sequence XQRLGNQWAVGFLM

(Modifications: X = Glp, Phe-12 = D-Phe, Gly-14 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 108437-87-2
PubChem ID 57340149
InChI Key NXZVGUQLNAVPLJ-VKXSZNMLSA-N
Smiles [H]N1[C@@H](CCC1=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1629.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.61 mL 3.07 mL 6.14 mL
5 mM 0.12 mL 0.61 mL 1.23 mL
10 mM 0.06 mL 0.31 mL 0.61 mL
50 mM 0.01 mL 0.06 mL 0.12 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Heinz-Erian et al (1987) [D-Phe12]Bombesin analogues: a new class of bombesin receptor antagonists. Am.J.Physiol. 252 G439 PMID: 2435173

Merali et al (1988) (D-Phe12) Bombesin and substance P analogues function as central bombesin receptor antagonists. Synapse 2 282 PMID: 2463692

Moody et al (1988) Localization of receptors for bombesin-like peptides in the rat brain. Ann.N.Y.Acad.Sci. 547 114 PMID: 2853589


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Keywords: Bombesin receptor antagonists GRP-Preferring Receptors BB1-3 Gastrin-Releasing Peptide-Preferring NMB-Preferring Neuromedin B-Preferring Bombesin Receptor Peptide

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