CyPPA
Biological Activity
Activator of small conductance Ca2+-activated K+ channels that displays selectivity for KCa2.2 (SK2) and KCa2.3 (SK3) channels (EC50 values are 5.6 and 14 μM for KCa2.3 and KCa2.2 respectively). Displays no activity at KCa2.1 (SK1) and KCa3.1 (IK) channels.
Technical Data
| M. Wt | 285.39 |
| Formula | C16H23N5 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 73029-73-9 |
| PubChem ID | 909822 |
| InChI Key | USEMRPYUFJNFQN-UHFFFAOYSA-N |
| Smiles | CC1=NC(N2N=C(C)C=C2C)=NC(NC3CCCCC3)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Product Datasheets
References
References are publications that support the biological activity of the product.
Hougaard et al (2007) Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels. Br.J.Pharmacol. 151 655 PMID: 17486140
If you know of a relevant reference for CyPPA, please let us know.
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Keywords: CyPPA, CyPPA supplier, activators, SK2, SK3, channels, Potassium, KCa, KCa2.2, KCa2.3, Channels, ca2+-activated, ca2+-dependent, K+, SKCa2, SKCa3, Ca2+-Activated, 2953, Tocris Bioscience
2 Citations for CyPPA
Citations are publications that use Tocris products. Selected citations for CyPPA include:
Abdulkareem et al (2016) Knockdown of the small conductance Ca(2+) -activated K(+) channels is potently cytotoxic in breast cancer cell lines. J Exp Clin Cancer Res 173 177 PMID: 26454020
Benton et al (2013) Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata. J Neurophysiol 109 2528 PMID: 23446695
Do you know of a great paper that uses CyPPA from Tocris? Please let us know.
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Literature in this Area
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Ion Channel Product Listing
A collection of around 500 products for ion channel research, the listing includes research tools for the study of:
- Ligand-gated ion channels
- Voltage-gated ion channels
- Other Ion Channels
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