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Submit ReviewCyPPA
Description: Activator of KCa2.2 and KCa2.3 channels
Chemical Name: N-Cyclohexyl-N-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-4-pyrimidinamine
Purity: ≥99% (HPLC)
Biological Activity
Activator of small conductance Ca2+-activated K+ channels that displays selectivity for KCa2.2 (SK2) and KCa2.3 (SK3) channels (EC50 values are 5.6 and 14 μM for KCa2.3 and KCa2.2 respectively). Displays no activity at KCa2.1 (SK1) and KCa3.1 (IK) channels.
Technical Data
| M. Wt | 285.39 |
| Formula | C16H23N5 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 73029-73-9 |
| PubChem ID | 909822 |
| InChI Key | USEMRPYUFJNFQN-UHFFFAOYSA-N |
| Smiles | CC1=NC(N2N=C(C)C=C2C)=NC(NC3CCCCC3)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets
References
References are publications that support the biological activity of the product.
Hougaard et al (2007) Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels. Br.J.Pharmacol. 151 655 PMID: 17486140
If you know of a relevant reference for CyPPA, please let us know.
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Keywords: CyPPA, CyPPA supplier, activators, SK2, SK3, channels, Potassium, KCa, KCa2.2, KCa2.3, Channels, ca2+-activated, ca2+-dependent, K+, SKCa2, SKCa3, Ca2+-Activated, 2953, Tocris Bioscience
2 Citations for CyPPA
Citations are publications that use Tocris products. Selected citations for CyPPA include:
Abdulkareem et al (2016) Knockdown of the small conductance Ca(2+) -activated K(+) channels is potently cytotoxic in breast cancer cell lines. J Exp Clin Cancer Res 173 177 PMID: 26454020
Benton et al (2013) Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata. J Neurophysiol 109 2528 PMID: 23446695
Do you know of a great paper that uses CyPPA from Tocris? Please let us know.
Reviews for CyPPA
Average Rating: 5 (Based on 1 Review.)
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CyPPA was used to study small conductance SK channel activation: Excellent publishable, performed ideally.
By
Eleanor Baxter on 10/23/2018
Assay Type: In Vitro
Species: Human
CyPPA was used to study small conductance SK channel activation along with other activators as a measure of comparison. The compound shows reasonable calcium activated potassium channel opening.
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