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Cat.No. 2953 - CyPPA | C16H23N5 | CAS No. 73029-73-9
Description: Activator of KCa2.2 and KCa2.3 channels
Chemical Name: N-Cyclohexyl-N-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-4-pyrimidinamine
Purity: ≥99% (HPLC)
Citations (2)

Biological Activity

Activator of small conductance Ca2+-activated K+ channels that displays selectivity for KCa2.2 (SK2) and KCa2.3 (SK3) channels (EC50 values are 5.6 and 14 μM for KCa2.3 and KCa2.2 respectively). Displays no activity at KCa2.1 (SK1) and KCa3.1 (IK) channels.

Technical Data

M. Wt 285.39
Formula C16H23N5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 73029-73-9
PubChem ID 909822
Smiles CC1=NC(N2N=C(C)C=C2C)=NC(NC3CCCCC3)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Product Datasheets

Safety Datasheet


References are publications that support the biological activity of the product.

Hougaard et al (2007) Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels. Br.J.Pharmacol. 151 655 PMID: 17486140

If you know of a relevant reference for CyPPA, please let us know.

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View all Calcium-Activated Potassium (KCa) Channel Activators

Keywords: CyPPA, CyPPA supplier, activators, SK2, SK3, channels, Potassium, KCa, KCa2.2, KCa2.3, Channels, ca2+-activated, ca2+-dependent, K+, SKCa2, SKCa3, Ca2+-Activated, 2953, Tocris Bioscience

2 Citations for CyPPA

Citations are publications that use Tocris products. Selected citations for CyPPA include:

Abdulkareem et al (2016) Knockdown of the small conductance Ca(2+) -activated K(+) channels is potently cytotoxic in breast cancer cell lines. J Exp Clin Cancer Res 173 177 PMID: 26454020

Benton et al (2013) Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata. J Neurophysiol 109 2528 PMID: 23446695

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