CyPPA

Pricing Availability Delivery Time Qty
Cat.No. 2953 - CyPPA | C16H23N5 | CAS No. 73029-73-9
Description: Activator of KCa2.2 and KCa2.3 channels
Chemical Name: N-Cyclohexyl-N-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-4-pyrimidinamine
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Activator of small conductance Ca2+-activated K+ channels that displays selectivity for KCa2.2 (SK2) and KCa2.3 (SK3) channels (EC50 values are 5.6 and 14 μM for KCa2.3 and KCa2.2 respectively). Displays no activity at KCa2.1 (SK1) and KCa3.1 (IK) channels.

Technical Data

M. Wt 285.39
Formula C16H23N5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 73029-73-9
PubChem ID 909822
InChI Key USEMRPYUFJNFQN-UHFFFAOYSA-N
Smiles CC1=NC(N2N=C(C)C=C2C)=NC(NC3CCCCC3)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.54 100
ethanol 28.54 100

Preparing Stock Solutions

The following data is based on the product molecular weight 285.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.5 mL 17.52 mL 35.04 mL
5 mM 0.7 mL 3.5 mL 7.01 mL
10 mM 0.35 mL 1.75 mL 3.5 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

Molarity Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hougaard et al (2007) Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels. Br.J.Pharmacol. 151 655 PMID: 17486140


If you know of a relevant reference for CyPPA, please let us know.

View Related Products by Product Action

View all Calcium-Activated Potassium (KCa) Channel Activators

Keywords: CyPPA, supplier, activators, SK2, SK3, channels, Potassium, KCa, KCa2.2, KCa2.3, Channels, ca2+-activated, ca2+-dependent, K+, SKCa2, SKCa3, Ca2+-Activated, Potassium, Channels, Tocris Bioscience

2 Citations for CyPPA

Citations are publications that use Tocris products. Selected citations for CyPPA include:

Abdulkareem et al (2016) Knockdown of the small conductance Ca(2+) -activated K(+) channels is potently cytotoxic in breast cancer cell lines. J Exp Clin Cancer Res 173 177 PMID: 26454020

Benton et al (2013) Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata. J Neurophysiol 109 2528 PMID: 23446695


Do you know of a great paper that uses CyPPA from Tocris? If so please let us know.

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Literature in this Area

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New Product Guide (Spring/Summer 2017)

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