Activator of small conductance Ca2+-activated K+ channels that displays selectivity for KCa2.2 (SK2) and KCa2.3 (SK3) channels (EC50 values are 5.6 and 14 μM for KCa2.3 and KCa2.2 respectively). Displays no activity at KCa2.1 (SK1) and KCa3.1 (IK) channels.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 285.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.5 mL||17.52 mL||35.04 mL|
|5 mM||0.7 mL||3.5 mL||7.01 mL|
|10 mM||0.35 mL||1.75 mL||3.5 mL|
|50 mM||0.07 mL||0.35 mL||0.7 mL|
References are publications that support the products' biological activity.
Hougaard et al (2007) Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels. Br.J.Pharmacol. 151 655 PMID: 17486140
If you know of a relevant reference for CyPPA, please let us know.
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Keywords: CyPPA, supplier, activators, SK2, SK3, channels, Potassium, KCa, KCa2.2, KCa2.3, Channels, ca2+-activated, ca2+-dependent, K+, SKCa2, SKCa3, Ca2+-Activated, Potassium, Channels, Ca2+-Activated, Potassium, Channels, Tocris Bioscience
2 Citations for CyPPA
Citations are publications that use Tocris products. Selected citations for CyPPA include:
Benton et al (2013) Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata. J Neurophysiol 109 2528 PMID: 23446695
Abdulkareem et al (2016) Knockdown of the small conductance Ca(2+) -activated K(+) channels is potently cytotoxic in breast cancer cell lines. J Exp Clin Cancer Res 173 177 PMID: 26454020
Do you know of a great paper that uses CyPPA from Tocris? If so please let us know.
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