CYN 154806

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Cat.No. 1843 - CYN 154806 | Ac-(4-Nitro)Phe-D-Cys-Tyr-D-Trp-Lys-Thr-Cys-D-Tyr-NH2 (Disulfide bridge: 2 - 7) | CAS No. 183658-72-2
Description: Selective sst2 antagonist
Datasheet
Citations (4)
Literature

Biological Activity

Potent and selective somatostatin sst2 receptor antagonist. pIC50 values are 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively.

Technical Data

M. Wt 1197.35
Formula C56H68N12O14S2
Sequence FCYWKTCY

(Modifications: Phe-1 = Ac-(4-nitro)Phe, Cys-2 = D-Cys, Trp-4 = D-Trp, Tyr-8 = D-Tyr & C-terminal amide, Disulfide bridge between 2 - 7)

Storage Desiccate at -20°C
CAS Number 183658-72-2
PubChem ID 16133842
InChI Key RDTVTSXTFYXNSG-HDNDNHAUSA-N
Smiles C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](CSSC[C@H](NC1=O)C(=O)N[C@H](CC1=CC=C(O)C=C1)C(N)=O)NC(=O)[C@H](CC1=CC=C(C=C1)[N+]([O-])=O)NC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1197.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.84 mL 4.18 mL 8.35 mL
5 mM 0.17 mL 0.84 mL 1.67 mL
10 mM 0.08 mL 0.42 mL 0.84 mL
50 mM 0.02 mL 0.08 mL 0.17 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bass et al (1996) Identification and characterization of novel somatostatin antagonists. Mol.Pharmacol. 50 709 PMID: 8863814

Feniuk et al (2000) Selective somatostatin sst2 receptor blockade with the novel cyclic octapeptide, CYN-154806. Neuropharmacology 39 1443 PMID: 10818260

Hannon et al (2002) Drug design at peptide receptors. Somatostatin receptor ligands. J.Mol.Neurosci. 18 15 PMID: 11931345


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Keywords: CYN 154806, supplier, Selective, sst2, antagonists, Receptors, Somatostatin, CYN154806, Somatostatin, Receptors, Tocris Bioscience

4 Citations for CYN 154806

Citations are publications that use Tocris products. Selected citations for CYN 154806 include:

Foong et al (2010) 5-HT(1A), SST(1), and SST(2) receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum. Neuroimmunomodulation 298 G384 PMID: 20007849

Elliott et al (2015) Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP. Am J Physiol Endocrinol Metab 308 E130 PMID: 25406263

Iwagaki et al (2013) Neurochemical characterisation of lamina II inhibitory interneurons that express GFP in the PrP-GFP mouse. Mol Pain 9 56 PMID: 24176114

Spitsin et al (2013) Analog of somatostatin vapreotide exhibits biological effects in vitro via interaction with neurokinin-1 receptor. J Leukoc Biol 20 247 PMID: 23921645


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