Potent and selective somatostatin sst2 receptor antagonist. pIC50 values are 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively.
(Modifications: Phe-1 = Ac-(4-nitro)Phe, Cys-2 = D-Cys, Trp-4 = D-Trp, Tyr-8 = D-Tyr & C-terminal amide, Disulfide bridge between 2 - 7)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Bass et al (1996) Identification and characterization of novel somatostatin antagonists. Mol.Pharmacol. 50 709 PMID: 8863814
Feniuk et al (2000) Selective somatostatin sst2 receptor blockade with the novel cyclic octapeptide, CYN-154806. Neuropharmacology 39 1443 PMID: 10818260
Hannon et al (2002) Drug design at peptide receptors. Somatostatin receptor ligands. J.Mol.Neurosci. 18 15 PMID: 11931345
If you know of a relevant reference for CYN 154806, please let us know.
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Keywords: CYN 154806, CYN 154806 supplier, Selective, sst2, antagonists, Receptors, Somatostatin, CYN154806, 1843, Tocris Bioscience
5 Citations for CYN 154806
Citations are publications that use Tocris products. Selected citations for CYN 154806 include:
Elliott et al (2015) Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP. Am J Physiol Endocrinol Metab 308 E130 PMID: 25406263
Spitsin et al (2013) Analog of somatostatin vapreotide exhibits biological effects in vitro via interaction with neurokinin-1 receptor. J Leukoc Biol 20 247 PMID: 23921645
Foong et al (2010) 5-HT(1A), SST(1), and SST(2) receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum. Neuroimmunomodulation 298 G384 PMID: 20007849
Yang et al (2010) Activation of submucosal 5-HT(3) receptors elicits a somatostatin-dependent inhibition of ion secretion in rat colon. Br J Pharmacol 159 1623 PMID: 20233224
Iwagaki et al (2013) Neurochemical characterisation of lamina II inhibitory interneurons that express GFP in the PrP-GFP mouse. Mol Pain 9 56 PMID: 24176114
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