CYN 154806

Pricing Availability   Qty
Description: Selective sst2 antagonist
Purity: ≥95% (HPLC)
Datasheet
Citations (8)
Reviews
Literature (3)

Biological Activity for CYN 154806

CYN 154806 is a potent and selective somatostatin sst2 receptor antagonist. pIC50 values are 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively.

Technical Data for CYN 154806

M. Wt 1197.35
Formula C56H68N12O14S2
Sequence FCYWKTCY

(Modifications: Phe-1 = Ac-(4-nitro)Phe, Cys-2 = D-Cys, Trp-4 = D-Trp, Tyr-8 = D-Tyr & C-terminal amide, Disulfide bridge: 2-7)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 183658-72-2
PubChem ID 16133842
InChI Key RDTVTSXTFYXNSG-HDNDNHAUSA-N
Smiles C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](CSSC[C@H](NC1=O)C(=O)N[C@H](CC1=CC=C(O)C=C1)C(N)=O)NC(=O)[C@H](CC1=CC=C(C=C1)[N+]([O-])=O)NC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CYN 154806

Solubility Soluble to 1 mg/ml in water

Product Datasheets for CYN 154806

Certificate of Analysis / Product Datasheet
Select another batch:

References for CYN 154806

References are publications that support the biological activity of the product.

Bass et al (1996) Identification and characterization of novel somatostatin antagonists. Mol.Pharmacol. 50 709 PMID: 8863814

Feniuk et al (2000) Selective somatostatin sst2 receptor blockade with the novel cyclic octapeptide, CYN-154806. Neuropharmacology 39 1443 PMID: 10818260

Hannon et al (2002) Drug design at peptide receptors. Somatostatin receptor ligands. J.Mol.Neurosci. 18 15 PMID: 11931345


If you know of a relevant reference for CYN 154806, please let us know.

View Related Products by Product Action

View all Somatostatin (sst) Receptor Antagonists

Keywords: CYN 154806, CYN 154806 supplier, Selective, sst2, antagonists, Receptors, Somatostatin, CYN154806, 1843, Tocris Bioscience

8 Citations for CYN 154806

Citations are publications that use Tocris products. Selected citations for CYN 154806 include:

Paramonov et al (2018) Targeting Somatostatin Receptors By Functionalized Mesoporous Silica Nanoparticles - Are We Striking Home?. Nanotheranostics 2 320 PMID: 30148051

Hastoy et al (2018) Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells. Sci Rep 8 16994 PMID: 30451893

Foong et al (2010) 5-HT(1A), SST(1), and SST(2) receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum. Neuroimmunomodulation 298 G384 PMID: 20007849

Iwagaki et al (2013) Neurochemical characterisation of lamina II inhibitory interneurons that express GFP in the PrP-GFP mouse. Mol Pain 9 56 PMID: 24176114


Do you know of a great paper that uses CYN 154806 from Tocris? Please let us know.

Reviews for CYN 154806

There are currently no reviews for this product. Be the first to review CYN 154806 and earn rewards!

Have you used CYN 154806?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR Product Listing

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Peptide Hormone Receptors Product Listing

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing
Cardiovascular Poster

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.