CYM 50769

Pricing Availability   Qty
Description: Novel non-peptide NPBWR1 antagonist
Alternative Names: ML250
Chemical Name: 5-Chloro-2-(9H-fluoren-9-yl)-4-(4-methoxyphenoxy)-3(2H)-pyridazinone
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for CYM 50769

CYM 50769 is a novel non-peptide antagonist of neuropeptide W/B receptor 1 (NPBWR1, GPR7) (IC50 = 0.12 μM).

Technical Data for CYM 50769

M. Wt 416.86
Formula C24H17ClN2O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1421365-63-0
PubChem ID 50904505
Smiles ClC(C=N4)=C(OC5=CC=C(OC)C=C5)C(N4C2C3=C(C=CC=C3)C1=CC=CC=C12)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CYM 50769

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 41.69 100

Preparing Stock Solutions for CYM 50769

The following data is based on the product molecular weight 416.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.4 mL 11.99 mL 23.99 mL
5 mM 0.48 mL 2.4 mL 4.8 mL
10 mM 0.24 mL 1.2 mL 2.4 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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References for CYM 50769

References are publications that support the biological activity of the product.

Guerrero et al (2013) SAR analysis of novel non-peptidic NPBWR1 (GPR7) antagonists. Bioorg.Med.Chem.Lett. 23 614 PMID: 23287738

If you know of a relevant reference for CYM 50769, please let us know.

View Related Products by Target

Keywords: CYM 50769, CYM 50769 supplier, NPBWR1, antagonists, neuropeptide, B, W, receptor, 1, CYM50769, ML250, GPR7, Other, Peptide, Receptors, 4948, Tocris Bioscience

Citations for CYM 50769

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.