CYM 50769

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Cat.No. 4948 - CYM 50769 | C24H17ClN2O3 | CAS No. 1421365-63-0
Description: Novel non-peptide NPBWR1 antagonist
Alternative Names: ML250
Chemical Name: 5-Chloro-2-(9H-fluoren-9-yl)-4-(4-methoxyphenoxy)-3(2H)-pyridazinone
Purity: ≥98% (HPLC)

Biological Activity

Novel non-peptide antagonist of neuropeptide W/B receptor 1 (NPBWR1, GPR7) (IC50 = 0.12 μM).

Compound Libraries

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Technical Data

M. Wt 416.86
Formula C24H17ClN2O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1421365-63-0
PubChem ID 50904505
Smiles ClC(C=N4)=C(OC5=CC=C(OC)C=C5)C(N4C2C3=C(C=CC=C3)C1=CC=CC=C12)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 41.69 100

Preparing Stock Solutions

The following data is based on the product molecular weight 416.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.4 mL 11.99 mL 23.99 mL
5 mM 0.48 mL 2.4 mL 4.8 mL
10 mM 0.24 mL 1.2 mL 2.4 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Guerrero et al (2013) SAR analysis of novel non-peptidic NPBWR1 (GPR7) antagonists. Bioorg.Med.Chem.Lett. 23 614 PMID: 23287738

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Keywords: NPBWR1 antagonists neuropeptide B W receptor 1 CYM50769 ML250 GPR7 ML250 Other Peptide Receptors

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