Cyclosomatostatin

Pricing Availability   Qty
Description: Non-selective sst antagonist
Alternative Names: Cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL])
Purity: ≥95% (HPLC)
Datasheet
Citations (5)
Reviews

Biological Activity for Cyclosomatostatin

Cyclosomatostatin is a non-selective somatostatin (sst) receptor antagonist. Blocks the effects of sst on airway β-adrenergic function, CRF-induced suppression of gastric empyting, modulation of ACh release and growth hormone, insulin and glucagon release. Reported to act as an sst receptor agonist in human neuroblastoma cell line SH-SY5Y.

Technical Data for Cyclosomatostatin

M. Wt 779.98
Formula C44H57N7O6
Sequence FWKT

(Modifications: Phe-1 = Aminoheptanoyl-Phe, Trp-2 = D-Trp, Thr-4 = Bn-Thr)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 84211-54-1
PubChem ID 122080
InChI Key YHVHQZYJGWGAKN-ZUWUZHNASA-N
Smiles C[C@@H](OCC1=CC=CC=C1)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)CCCCCCNC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Cyclosomatostatin

Solubility Soluble to 1 mg/ml in 20% ethanol / water

Product Datasheets for Cyclosomatostatin

Certificate of Analysis / Product Datasheet
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References for Cyclosomatostatin

References are publications that support the biological activity of the product.

Fries et al (1982) Somatostatin antagonist analog increases GH, Ins, and glucagon release in the rat. Peptides 3 811 PMID: 6129618

Stirnweis et al (2002) The putative somatostatin antagonist, cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL]), may act as a potent antiproliferative agonist. Peptides 23 1503 PMID: 12182954

Guo et al (2008) Somatostatin inhibits activation of dorsal cutaneous primary afferents induced by antidromic stimulation of primary afferents from an adjacent segment in the rat. Brain Res. 1229 61 PMID: 18640104


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Keywords: Cyclosomatostatin, Cyclosomatostatin supplier, Non-Selective, sst, receptor, antagonists, Receptors, Somatostatin, Cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL]), 3493, Tocris Bioscience

5 Citations for Cyclosomatostatin

Citations are publications that use Tocris products. Selected citations for Cyclosomatostatin include:

Takashi et al (2022) Somatostatin-evoked Aβ catabolism in the brain: Mechanistic involvement of α-endosulfine-KATP channel pathway. Mol Psychiatry 27 1816-1828 PMID: 34737456

Chiara et al (2021) Enhanced neprilysin-mediated degradation of hippocampal Aβ42 with a somatostatin peptide that enters the brain. Theranostics 11 789-804 PMID: 33391505

Elliott et al (2015) Somatostatin and Ins mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP. Am J Physiol Endocrinol Metab 308 E130 PMID: 25406263

Anaëlle et al (2020) Somatostatin enhances visual processing and perception by suppressing excitatory inputs to parvalbumin-positive interneurons in V1. Sci Adv 6 eaaz0517 PMID: 32494634


Do you know of a great paper that uses Cyclosomatostatin from Tocris? Please let us know.

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