Cyclosomatostatin

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Cat.No. 3493 - Cyclosomatostatin | cyclo(Aminoheptanoyl-Phe-DTrp-Lys-(Bn)Thr) | CAS No. 84211-54-1
Description: Non-selective sst receptor antagonist
Alternative Names: Cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL])
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Non-selective somatostatin (sst) receptor antagonist. Blocks the effects of sst on airway β-adrenergic function, CRF-induced suppression of gastric empyting, modulation of ACh release and growth hormone, insulin and glucagon release. Reported to act as an sst receptor agonist in human neuroblastoma cell line SH-SY5Y.

Technical Data

M. Wt 779.98
Formula C44H57N7O6
Sequence FWKT

(Modifications: Phe-1 = Aminoheptanoyl-Phe, Trp-1 = DTrp, Thr-4 = Bn-Thr)

Storage Store at -20°C
CAS Number 84211-54-1
PubChem ID 122080
InChI Key YHVHQZYJGWGAKN-ZUWUZHNASA-N
Smiles C[C@@H](OCC1=CC=CC=C1)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)CCCCCCNC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in 20% ethanol / water

Preparing Stock Solutions

The following data is based on the product molecular weight 779.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.28 mL 6.41 mL 12.82 mL
5 mM 0.26 mL 1.28 mL 2.56 mL
10 mM 0.13 mL 0.64 mL 1.28 mL
50 mM 0.03 mL 0.13 mL 0.26 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Fries et al (1982) Somatostatin antagonist analog increases GH, insulin, and glucagon release in the rat. Peptides 3 811 PMID: 6129618

Stirnweis et al (2002) The putative somatostatin antagonist, cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL]), may act as a potent antiproliferative agonist. Peptides 23 1503 PMID: 12182954

Guo et al (2008) Somatostatin inhibits activation of dorsal cutaneous primary afferents induced by antidromic stimulation of primary afferents from an adjacent segment in the rat. Brain Res. 1229 61 PMID: 18640104


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Keywords: Cyclosomatostatin, supplier, Non-Selective, sst, receptor, antagonists, Receptors, Somatostatin, Cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL]), Somatostatin, Receptors, Somatostatin, Receptors, Tocris Bioscience

1 Citation for Cyclosomatostatin

Citations are publications that use Tocris products. Selected citations for Cyclosomatostatin include:

Elliott et al (2015) Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP. Am J Physiol Endocrinol Metab 308 E130 PMID: 25406263


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