Non-selective somatostatin (sst) receptor antagonist. Blocks the effects of sst on airway β-adrenergic function, CRF-induced suppression of gastric empyting, modulation of ACh release and growth hormone, insulin and glucagon release. Reported to act as an sst receptor agonist in human neuroblastoma cell line SH-SY5Y.
(Modifications: Phe-1 = Aminoheptanoyl-Phe, Trp-1 = DTrp, Thr-4 = Bn-Thr)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in 20% ethanol / water|
Preparing Stock Solutions
The following data is based on the product molecular weight 779.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.28 mL||6.41 mL||12.82 mL|
|5 mM||0.26 mL||1.28 mL||2.56 mL|
|10 mM||0.13 mL||0.64 mL||1.28 mL|
|50 mM||0.03 mL||0.13 mL||0.26 mL|
References are publications that support the biological activity of the product.
Fries et al (1982) Somatostatin antagonist analog increases GH, insulin, and glucagon release in the rat. Peptides 3 811 PMID: 6129618
Stirnweis et al (2002) The putative somatostatin antagonist, cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL]), may act as a potent antiproliferative agonist. Peptides 23 1503 PMID: 12182954
Guo et al (2008) Somatostatin inhibits activation of dorsal cutaneous primary afferents induced by antidromic stimulation of primary afferents from an adjacent segment in the rat. Brain Res. 1229 61 PMID: 18640104
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Keywords: Cyclosomatostatin, Cyclosomatostatin supplier, Non-Selective, sst, receptor, antagonists, Receptors, Somatostatin, Cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL]), 3493, Tocris Bioscience
1 Citation for Cyclosomatostatin
Citations are publications that use Tocris products. Selected citations for Cyclosomatostatin include:
Elliott et al (2015) Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP. Am J Physiol Endocrinol Metab 308 E130 PMID: 25406263
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Literature in this Area
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