NLRP3 inhibitor (Kd = 500 nM); directly binds to ATP-binding motif of NLRP3 NACHT domain. Blocks NLRP3 inflammasome assembly and activation. Displays therapeutic effects on mouse models of cryopyrin-associated autoinflammatory syndrome (CAPS) and type 2 diabetes. Exhibits no activity for hERG (10 μM).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||8.47||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 423.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||11.81 mL||59.04 mL||118.08 mL|
|1 mM||2.36 mL||11.81 mL||23.62 mL|
|2 mM||1.18 mL||5.9 mL||11.81 mL|
|10 mM||0.24 mL||1.18 mL||2.36 mL|
References are publications that support the biological activity of the product.
Jiang et al (2017) Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. J.Exp.Med. 214 3219 PMID: 29021150
If you know of a relevant reference for CY 09, please let us know.
View Related Products by Product Action
Keywords: CY 09, CY 09 supplier, CY09, inflammasomes, NLRP3, NOD-like, receptors, inhibitors, inhibits, diabetes, anti-inflammatory, ATP, Inflammasomes, 6436, Tocris Bioscience
Citations for CY 09
Citations are publications that use Tocris products.
Currently there are no citations for CY 09. Do you know of a great paper that uses CY 09 from Tocris? Please let us know.
Reviews for CY 09
There are currently no reviews for this product. Be the first to review CY 09 and earn rewards!
Have you used CY 09?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.