CY 09

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Cat.No. 6436 - CY 09 | C19H12F3NO3S2 | CAS No. 1073612-91-5
Description: NLRP3 inhibitor; active in vivo
Chemical Name: 4-[[4-Oxo-2-thioxo-3-[[3-(trifluoromethyl)phenyl]methyl]-5-thiazolidinylidene]methyl]benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

NLRP3 inhibitor (Kd = 500 nM); directly binds to ATP-binding motif of NLRP3 NACHT domain. Blocks NLRP3 inflammasome assembly and activation. Displays therapeutic effects on mouse models of cryopyrin-associated autoinflammatory syndrome (CAPS) and type 2 diabetes. Exhibits no activity for hERG (10 μM).

Technical Data

M. Wt 423.43
Formula C19H12F3NO3S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1073612-91-5
PubChem ID 44561595
InChI Key DJTINRHPPGAPLD-DHDCSXOGSA-N
Smiles OC(C1=CC=C(C=C1)/C=C2SC(N(C/2=O)CC3=CC(C(F)(F)F)=CC=C3)=S)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.47 20 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 423.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.81 mL 59.04 mL 118.08 mL
1 mM 2.36 mL 11.81 mL 23.62 mL
2 mM 1.18 mL 5.9 mL 11.81 mL
10 mM 0.24 mL 1.18 mL 2.36 mL

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References

References are publications that support the biological activity of the product.

Jiang et al (2017) Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. J.Exp.Med. 214 3219 PMID: 29021150


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Keywords: CY 09, CY 09 supplier, CY09, inflammasomes, NLRP3, NOD-like, receptors, inhibitors, inhibits, diabetes, anti-inflammatory, ATP, Inflammasomes, 6436, Tocris Bioscience

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