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NLRP3 inhibitor (Kd = 500 nM); directly binds to ATP-binding motif of NLRP3 NACHT domain. Blocks NLRP3 inflammasome assembly and activation. Displays therapeutic effects on mouse models of cryopyrin-associated autoinflammatory syndrome (CAPS) and type 2 diabetes. Exhibits no activity for hERG (10 μM).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||8.47||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 423.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||11.81 mL||59.04 mL||118.08 mL|
|1 mM||2.36 mL||11.81 mL||23.62 mL|
|2 mM||1.18 mL||5.9 mL||11.81 mL|
|10 mM||0.24 mL||1.18 mL||2.36 mL|
References are publications that support the biological activity of the product.
Jiang et al (2017) Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. J.Exp.Med. 214 3219 PMID: 29021150
If you know of a relevant reference for CY 09, please let us know.
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Keywords: CY 09, CY 09 supplier, CY09, inflammasomes, NLRP3, NOD-like, receptors, inhibitors, inhibits, diabetes, anti-inflammatory, ATP, Inflammasomes, 6436, Tocris Bioscience
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