CX 546

Pricing Availability   Qty
Description: AMPA potentiator
Chemical Name: (2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (5)

Biological Activity for CX 546

CX 546 is an AMPA receptor potentiator. Binds specifically to the agonist bound non-desensitized receptor, most likely destabilizing the desensitized receptor conformation. Enhances cognitive function in rats. Neuroprotective in mice undergoing repeat ketamine anesthesia.

Technical Data for CX 546

M. Wt 247.29
Formula C14H17NO3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 215923-54-9
PubChem ID 2890
InChI Key LJUNPHMOGNFFOS-UHFFFAOYSA-N
Smiles O=C(N3CCCCC3)C2=CC1=C(C=C2)OCCO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CX 546

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.73 100
ethanol 24.73 100

Preparing Stock Solutions for CX 546

The following data is based on the product molecular weight 247.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.04 mL 20.22 mL 40.44 mL
5 mM 0.81 mL 4.04 mL 8.09 mL
10 mM 0.4 mL 2.02 mL 4.04 mL
50 mM 0.08 mL 0.4 mL 0.81 mL

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Product Datasheets for CX 546

Certificate of Analysis / Product Datasheet
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References for CX 546

References are publications that support the biological activity of the product.

Nagararjan et al (2001) Mechanism and impact of allosteric AMPA receptor modulation by the ampakine TM CX546. Neuropharmacology. 41 650 PMID: 11640919

O'Neill et al (2004) AMPA receptor potentiators for the treatment of CNS disorders. Curr.Drug Targets CNS Neurol.Disord. 3 181 PMID: 15180479

Shimazaki et al (2007) Blockade of the metabotropic glutamate 2/3 receptors enhances social memory via the AMPA receptor in rats. Eur.J.Pharmacol. 575 94 PMID: 17727837

Huang et al (2016) Post-anesthesia AMPA receptor potentiation prevents anesthesia-induced learning and synaptic deficits. Sci.Transl.Med. 8 ra85 PMID: 27334260


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Keywords: CX 546, CX 546 supplier, AMPA, receptor, potentiator, Glutamate, Receptors, iGluR, Ionotropic, CX546, 2980, Tocris Bioscience

Citations for CX 546

Citations are publications that use Tocris products.

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Reviews for CX 546

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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