CX 546

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Cat.No. 2980 - CX 546 | C14H17NO3 | CAS No. 215923-54-9
Description: AMPA receptor potentiator
Chemical Name: (2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

AMPA receptor potentiator. Binds specifically to the agonist bound non-desensitized receptor, most likely destabilizing the desensitized receptor conformation. Enhances cognitive function in rats. Neuroprotective in mice undergoing repeat ketamine anesthesia.

Technical Data

M. Wt 247.29
Formula C14H17NO3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 215923-54-9
PubChem ID 2890
InChI Key LJUNPHMOGNFFOS-UHFFFAOYSA-N
Smiles O=C(N3CCCCC3)C2=CC1=C(C=C2)OCCO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.73 100
ethanol 24.73 100

Preparing Stock Solutions

The following data is based on the product molecular weight 247.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.04 mL 20.22 mL 40.44 mL
5 mM 0.81 mL 4.04 mL 8.09 mL
10 mM 0.4 mL 2.02 mL 4.04 mL
50 mM 0.08 mL 0.4 mL 0.81 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Nagararjan et al (2001) Mechanism and impact of allosteric AMPA receptor modulation by the ampakine TM CX546. Neuropharmacology. 41 650 PMID: 11640919

O'Neill et al (2004) AMPA receptor potentiators for the treatment of CNS disorders. Curr.Drug Targets CNS Neurol.Disord. 3 181 PMID: 15180479

Shimazaki et al (2007) Blockade of the metabotropic glutamate 2/3 receptors enhances social memory via the AMPA receptor in rats. Eur.J.Pharmacol. 575 94 PMID: 17727837

Huang et al (2016) Post-anesthesia AMPA receptor potentiation prevents anesthesia-induced learning and synaptic deficits. Sci.Transl.Med. 8 ra85 PMID: 7334260


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Keywords: CX 546, supplier, AMPA, receptor, potentiator, Glutamate, Receptors, iGluR, Ionotropic, CX546, AMPA, Receptors, Tocris Bioscience

Citations for CX 546

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Pathways for CX 546

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