CVT 313

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Cat.No. 6174 - CVT 313 | C20H28N6O3 | CAS No. 199986-75-9
Description: cdk2 inhibitor
Chemical Name: 2,2'-[[6-[[(4-Methoxyphenyl)methyl]amino]-9-(1-methylethyl)-9H-purin-2-yl]imino]bis[ethanol]
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

cdk2 inhibitor (IC50 = 0.5 μM). Exhibits >8-fold selectivity for CDK2 over CDK1 and CDK4 (IC50 values are 4.2 and 215 μM, respectively). Inhibits proliferation rat neonatal aortic smooth muscle cells and a range of tumor cells lines in vitro. Inhibits restenosis in a rat carotid artery injury model.

Technical Data

M. Wt 400.47
Formula C20H28N6O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 199986-75-9
PubChem ID 6918386
InChI Key NQVIIUBWMBHLOZ-UHFFFAOYSA-N
Smiles COC1=CC=C(C=C1)CNC2=NC(N(CCO)CCO)=NC3=C2N=CN3C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.05 100
ethanol 40.05 100

Preparing Stock Solutions

The following data is based on the product molecular weight 400.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.5 mL 12.49 mL 24.97 mL
5 mM 0.5 mL 2.5 mL 4.99 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Brooks et al (1997) CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation. J.Biol.Chem. 272 29207 PMID: 9360999


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Keywords: CVT 313, supplier, CVT313, cdk2, cyclin, dependent, kinase, 2, inhibitors, inhibits, neointimal, proliferation, restenosis, Cyclin-dependent, Kinase, Cyclin-dependent, Kinase, Tocris Bioscience

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