CVT 313

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Cat.No. 6174 - CVT 313 | C20H28N6O3 | CAS No. 199986-75-9
Description: Cdk2 and cdk5 inhibitor
Chemical Name: 2,2'-[[6-[[(4-Methoxyphenyl)methyl]amino]-9-(1-methylethyl)-9H-purin-2-yl]imino]bis[ethanol]
Purity: ≥98% (HPLC)
Citations (1)
Literature (4)

Biological Activity

Cyclin-dependent kinase 2 (cdk2) inhibitor (reported IC50 values are 0.18 to 0.5 μM). Also inhibits cdk5 in sub-micromolar range (IC50 = 0.42 μM). Displays >7-fold selectivity for cdk2 and cdk5 over other cdks. Inhibits proliferation rat neonatal aortic smooth muscle cells and a range of tumor cells lines in vitro. Inhibits restenosis in a rat carotid artery injury model.

Compound Libraries

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Technical Data

M. Wt 400.47
Formula C20H28N6O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 199986-75-9
PubChem ID 6918386

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 40.05 100
ethanol 40.05 100

Preparing Stock Solutions

The following data is based on the product molecular weight 400.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.5 mL 12.49 mL 24.97 mL
5 mM 0.5 mL 2.5 mL 4.99 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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References are publications that support the biological activity of the product.

Brooks et al (1997) CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation. J.Biol.Chem. 272 29207 PMID: 9360999

Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987

If you know of a relevant reference for CVT 313, please let us know.

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Keywords: CVT 313, CVT 313 supplier, CVT313, cdk2, cyclin, dependent, kinase, 2, inhibitors, inhibits, neointimal, proliferation, restenosis, Cyclin-dependent, Kinase, 6174, Tocris Bioscience

1 Citation for CVT 313

Citations are publications that use Tocris products. Selected citations for CVT 313 include:

Musa et al (2019) Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes. Nat Commun 10 4128 PMID: 31511524

Do you know of a great paper that uses CVT 313 from Tocris? Please let us know.

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Literature in this Area

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