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Submit ReviewCV 1808
Description: Non-selective adenosine A2 receptor agonist
Chemical Name: 2-Phenylaminoadenosine
Purity: ≥99% (HPLC)
Biological Activity for CV 1808
CV 1808 is an adenosine A2 receptor agonist. Coronary vasodilator, antihypertensive and antipsychotic following systemic administration in vivo.
Technical Data for CV 1808
| M. Wt | 358.36 |
| Formula | C16H18N6O4 |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 53296-10-9 |
| PubChem ID | 6917803 |
| InChI Key | SCNILGOVBBRMBK-SDBHATRESA-N |
| Smiles | O[C@@H]1[C@@H](CO)O[C@@H](N(C=N3)C2=C3C(N)=NC(NC4=CC=CC=C4)=N2)[C@@H]1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CV 1808
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.58 | 10 |
Preparing Stock Solutions for CV 1808
The following data is based on the product molecular weight 358.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.9 mL | 139.52 mL | 279.05 mL |
| 0.5 mM | 5.58 mL | 27.9 mL | 55.81 mL |
| 1 mM | 2.79 mL | 13.95 mL | 27.9 mL |
| 5 mM | 0.56 mL | 2.79 mL | 5.58 mL |
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Product Datasheets for CV 1808
References for CV 1808
References are publications that support the biological activity of the product.
Abiru et al (1991) The antihypertensive effect of 2-alkynyladenosines and the selective affinity for adenosine A2 receptors. Eur.J.Pharmacol. 196 69 PMID: 1874281
Martin et al (1993) Adenosine agonists reduce conditioned avoidance responding in the rat. Pharmacol.Biochem.Behav. 45 951 PMID: 8105493
Marumoto et al (1975) Synthesis and coronary vasodilating activity of 2-substituted adenosines. Chem.Pharm.Bull. 23 759 PMID: 1182861
If you know of a relevant reference for CV 1808, please let us know.
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Keywords: CV 1808, CV 1808 supplier, Non-Selective, adenosines, A2, receptor, agonists, A2B, Receptors, A2A, CV1808, Adenosine, 1710, Tocris Bioscience
2 Citations for CV 1808
Citations are publications that use Tocris products. Selected citations for CV 1808 include:
Baba et al (2018) Folliculin Regulates Osteoclastogenesis Through Metabolic Regulation. J Bone Miner Res 33 1785 PMID: 29893999
Kan et al (2012) Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway. J Virol 86 10338 PMID: 22787201
Do you know of a great paper that uses CV 1808 from Tocris? Please let us know.
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