CU CPT 22

Pricing Availability Delivery Time Qty
Cat.No. 4884 - CU CPT 22 | C19H22O7 | CAS No. 1416324-85-0
Description: Selective TLR1/2 inhibitor
Chemical Name: 3,4,6-Trihydroxy-2-methoxy-5-oxo-5H-benzocycloheptene-8-carboxylic acid hexyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature
Pathways

Biological Activity

Selective toll-like receptor 1/2 (TLR1/2) inhibitor (IC50 = 0.58 μM). Exhibits no activity at TLR2/TLR6, TLR3, TLR4 and TLR7 or a panel of 10 representative kinases. Inhibits the release of proinflammatory cytokines TNF-α and IL-1β.

Licensing Information

Sold under license from the University of Colorado

Technical Data

M. Wt 362.37
Formula C19H22O7
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1416324-85-0
PubChem ID 71503400
InChI Key UBQFTTUFRSSOHE-UHFFFAOYSA-N
Smiles O=C1C(O)=CC(C(OCCCCCC)=O)=CC2=C1C(O)=C(O)C(OC)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 18.12 50
DMSO 36.24 100

Preparing Stock Solutions

The following data is based on the product molecular weight 362.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.76 mL 13.8 mL 27.6 mL
5 mM 0.55 mL 2.76 mL 5.52 mL
10 mM 0.28 mL 1.38 mL 2.76 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Cheng et al (2012) Discovery of small-molecule inhibitors of the TLR1/TLR2 complex. Angew Chem.Int.Ed.Engl. 51 12246 PMID: 22969053


If you know of a relevant reference for CU CPT 22, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Toll-like Receptor Inhibitors

Keywords: CU CPT 22, supplier, CUCPT22, toll-like, receptors, inhibitors, inhibits, selective, proinflammatory, cytokines, TLR, TLR1, TLR2, TRL1/TLR2, Toll-like, Receptors, Toll-like, Receptors, Tocris Bioscience

1 Citation for CU CPT 22

Citations are publications that use Tocris products. Selected citations for CU CPT 22 include:

Ghonime et al (2015) Inflammasome priming is similar for francisella species that differentially induce inflammasome activation. Nucleic Acids Res 10 e0127278 PMID: 25993107


Do you know of a great paper that uses CU CPT 22 from Tocris? If so please let us know.

Reviews for CU CPT 22

There are currently no reviews for this product. Be the first to review CU CPT 22 and earn rewards!

Have you used CU CPT 22?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation

Pathways for CU CPT 22

Toll-like Receptor

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.