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Cat.No. 4884 - CU CPT 22 | C19H22O7 | CAS No. 1416324-85-0
Description: Selective TLR1/2 inhibitor
Chemical Name: 3,4,6-Trihydroxy-2-methoxy-5-oxo-5H-benzocycloheptene-8-carboxylic acid hexyl ester
Purity: ≥98% (HPLC)
Citations (2)
Literature (2)
Pathways (1)

Biological Activity

Selective toll-like receptor 1/2 (TLR1/2) inhibitor (IC50 = 0.58 μM). Exhibits no activity at TLR2/TLR6, TLR3, TLR4 and TLR7 or a panel of 10 representative kinases. Inhibits the release of proinflammatory cytokines TNF-α and IL-1β.

Licensing Information

Sold under license from the University of Colorado

Technical Data

M. Wt 362.37
Formula C19H22O7
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1416324-85-0
PubChem ID 71503400
Smiles O=C1C(O)=CC(C(OCCCCCC)=O)=CC2=C1C(O)=C(O)C(OC)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 36.24 100
ethanol 18.12 50

Preparing Stock Solutions

The following data is based on the product molecular weight 362.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.76 mL 13.8 mL 27.6 mL
5 mM 0.55 mL 2.76 mL 5.52 mL
10 mM 0.28 mL 1.38 mL 2.76 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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References are publications that support the biological activity of the product.

Cheng et al (2012) Discovery of small-molecule inhibitors of the TLR1/TLR2 complex. Angew Chem.Int.Ed.Engl. 51 12246 PMID: 22969053

If you know of a relevant reference for CU CPT 22, please let us know.

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Keywords: CU CPT 22, CU CPT 22 supplier, CUCPT22, toll-like, receptors, inhibitors, inhibits, selective, proinflammatory, cytokines, TLR, TLR1, TLR2, TRL1/TLR2, Toll-like, Receptors, 4884, Tocris Bioscience

2 Citations for CU CPT 22

Citations are publications that use Tocris products. Selected citations for CU CPT 22 include:

Ahn et al (2019) Nonsaponin fraction of Korean Red Ginseng attenuates cytokine production via inhibition of TLR4 expression. J Ginseng Res 43 291 PMID: 30976167

Ghonime et al (2015) Inflammasome priming is similar for francisella species that differentially induce inflammasome activation. Nucleic Acids Res 10 e0127278 PMID: 25993107

Do you know of a great paper that uses CU CPT 22 from Tocris? Please let us know.

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Literature in this Area

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Pathways for CU CPT 22

Toll-like Receptor

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.