CU CPT 22
Selective toll-like receptor 1/2 (TLR1/2) inhibitor (IC50 = 0.58 μM). Exhibits no activity at TLR2/TLR6, TLR3, TLR4 and TLR7 or a panel of 10 representative kinases. Inhibits the release of proinflammatory cytokines TNF-α and IL-1β.
Sold under license from the University of Colorado
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 362.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.76 mL||13.8 mL||27.6 mL|
|5 mM||0.55 mL||2.76 mL||5.52 mL|
|10 mM||0.28 mL||1.38 mL||2.76 mL|
|50 mM||0.06 mL||0.28 mL||0.55 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Cheng et al (2012) Discovery of small-molecule inhibitors of the TLR1/TLR2 complex. Angew Chem.Int.Ed.Engl. 51 12246 PMID: 22969053
If you know of a relevant reference for CU CPT 22, please let us know.
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Keywords: CUCPT22 toll-like receptors inhibitors inhibits selective proinflammatory cytokines TLR TLR1 TLR2 TRL1/TLR2 Toll-like Receptors
1 Citation for CU CPT 22
Citations are publications that use Tocris products. Selected citations for CU CPT 22 include:
Ghonime et al (2015) Inflammasome priming is similar for francisella species that differentially induce inflammasome activation. Nucleic Acids Res 10 e0127278 PMID: 25993107
Do you know of a great paper that uses CU CPT 22 from Tocris? If so please let us know.