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Description: Negative control for CSN5i-3 (Cat. No. 7089)
Chemical Name: 3-(Difluoromethyl)-N-(6-((5R,6R)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl)-[1,10-biphenyl]-3-yl)-1-isopropyl-1H-pyrazole-5-carboxamide
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for CSN5i-3-NEG

CSN5i-3-NEG is the negative control for CSN5i-3 (Cat. No.7089).

Technical Data for CSN5i-3-NEG

M. Wt 505.57
Formula C28H29F2N5O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2863607-74-1
PubChem ID 145712311
Smiles CC(N1N=C(C(F)F)C=C1C(NC2=CC(C3=CC=CC=C3)=C([C@@H]4[C@@H](CCCC5=CN=CN45)O)C=C2)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CSN5i-3-NEG

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 50.56 100

Preparing Stock Solutions for CSN5i-3-NEG

The following data is based on the product molecular weight 505.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.98 mL 9.89 mL 19.78 mL
5 mM 0.4 mL 1.98 mL 3.96 mL
10 mM 0.2 mL 0.99 mL 1.98 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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References for CSN5i-3-NEG

References are publications that support the biological activity of the product.

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View all Ubiquitin E3 Ligase Controls

Keywords: CSN5i-3-NEG, CSN5i-3-NEG supplier, negative, controls, CSN5, COP9, signalosome, antitumour, antitumor, Constitutive, photomorphogenesis, 9, NEDD8, neddylation, cullin-ring, CRL, Ubiquitin, E3, Ligases, 7532, Tocris Bioscience

Citations for CSN5i-3-NEG

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Targeted Protein Degradation Research Product Guide

Targeted Protein Degradation Research Product Guide

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  • Ubiquitin-Proteasome System Proteins
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Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Targeted Protein Degradation Poster

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Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia