CP 465022 hydrochloride

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Cat.No. 2932 - CP 465022 hydrochloride | C26H24ClFN4O.HCl | CAS No. 1785666-59-2
Description: Selective and non-competitive AMPA antagonist
Chemical Name: 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinone hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (10)

Biological Activity

Selective, non-competitive AMPA antagonist (IC50 = 25 nM in rat cortical neurons) that displays potent anticonvulsant activity. Also significantly blocks the persistent component of Nav1.6 channel activity. Brain penetrant and orally active.

Technical Data

M. Wt 499.41
Formula C26H24ClFN4O.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1785666-59-2
PubChem ID 53251536
InChI Key YKYDGCRJPYLXHY-GVYCEHEKSA-N
Smiles O=C2N(C3=CC=CC=C3Cl)C(/C=C/C4=NC(CN(CC)CC)=CC=C4)=NC1=CC=C(F)C=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 4.99 10
DMSO 49.94 100

Preparing Stock Solutions

The following data is based on the product molecular weight 499.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2 mL 10.01 mL 20.02 mL
5 mM 0.4 mL 2 mL 4 mL
10 mM 0.2 mL 1 mL 2 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Lazaro et al (2002) Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist. Neuropharmacology 42 143 PMID: 11804610

Menniti et al (2003) CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo. Stroke 34 171 PMID: 12511770

Welch et al (2008) Traditional AMPA receptor antagonists partially block Nav1.6-mediated persistent current. Neuropharmacology 55 1165 PMID: 18687344


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Citations for CP 465022 hydrochloride

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