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Submit ReviewCP 465022 hydrochloride
Description: Selective and non-competitive AMPA antagonist
Chemical Name: 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinone hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for CP 465022 hydrochloride
CP 465022 hydrochloride is a selective, non-competitive AMPA antagonist (IC50 = 25 nM in rat cortical neurons) that displays potent anticonvulsant activity. Also significantly blocks the persistent component of Nav1.6 channel activity. Brain penetrant and orally active.
Technical Data for CP 465022 hydrochloride
| M. Wt | 499.41 |
| Formula | C26H24ClFN4O.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1785666-59-2 |
| PubChem ID | 53251536 |
| InChI Key | YKYDGCRJPYLXHY-GVYCEHEKSA-N |
| Smiles | O=C2N(C3=CC=CC=C3Cl)C(/C=C/C4=NC(CN(CC)CC)=CC=C4)=NC1=CC=C(F)C=C12.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CP 465022 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.94 | 100 |
Preparing Stock Solutions for CP 465022 hydrochloride
The following data is based on the product molecular weight 499.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2 mL | 10.01 mL | 20.02 mL |
| 5 mM | 0.4 mL | 2 mL | 4 mL |
| 10 mM | 0.2 mL | 1 mL | 2 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
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Product Datasheets for CP 465022 hydrochloride
References for CP 465022 hydrochloride
References are publications that support the biological activity of the product.
Lazaro et al (2002) Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist. Neuropharmacology 42 143 PMID: 11804610
Menniti et al (2003) CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo. Stroke 34 171 PMID: 12511770
Welch et al (2008) Traditional AMPA receptor antagonists partially block Nav1.6-mediated persistent current. Neuropharmacology 55 1165 PMID: 18687344
If you know of a relevant reference for CP 465022 hydrochloride, please let us know.
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