CP 376395 hydrochloride

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Cat.No. 3212 - CP 376395 hydrochloride | C21H30N2O.HCl | CAS No. 1013933-37-3
Description: Potent and selective CRF1 antagonist
Chemical Name: N-(1-Ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-4-pyridinamine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Potent and selective CRF1 receptor antagonist (Ki values are 12 and >10000 nM for CRF1 and CRF2 receptors respectively). Attenuates CRF-induced activation of the HPA axis in vivo following i.v. administration. Orally active.

Compound Libraries

CP 376395 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 362.94
Formula C21H30N2O.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1013933-37-3
PubChem ID 24806455
InChI Key UDIOZDHQQNYISB-UHFFFAOYSA-N
Smiles CC1=CC(NC(CC)CC)=C(C)C(OC2=C(C)C=C(C)C=C2C)=N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 36.29 100
DMSO 36.29 100
ethanol 36.29 100
water 18.15 50

Preparing Stock Solutions

The following data is based on the product molecular weight 362.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.76 mL 13.78 mL 27.55 mL
5 mM 0.55 mL 2.76 mL 5.51 mL
10 mM 0.28 mL 1.38 mL 2.76 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Chen et al (2008) 2-Aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists. J.Med.Chem. 51 1385 PMID: 18288792

Hollenstein et al (2013) Structure of class B GPCR corticotropin-releasing factor receptor 1. Nature 499 438 PMID: 23863939


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Keywords: CP 376395 hydrochloride, supplier, Potent, selective, CRF1, antagonists, Corticotropin-Releasing, Factor1, Receptors, CP376395, hydrochloride, CRF1, Receptors, CRF1, Receptors, Tocris Bioscience

2 Citations for CP 376395 hydrochloride

Citations are publications that use Tocris products. Selected citations for CP 376395 hydrochloride include:

Kean et al (2015) Conformational thermostabilisation of corticotropin releasing factor receptor 1. Mol Pain 5 11954 PMID: 26159865

Boyson et al (2014) Social stress and CRF-dopamine interactions in the VTA: role in long-term escalation of cocaine self-administration. J Neurosci 34 6659 PMID: 24806691


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