CP 31398 dihydrochloride

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Cat.No. 3023 - CP 31398 dihydrochloride | C22H26N4O.2HCl | CAS No. 1217195-61-3
Description: p53-stabilizing agent
Chemical Name: N'-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine dihydrochloride
Purity: ≥99% (HPLC)
Citations (2)
Literature (2)
Pathways (1)

Biological Activity for CP 31398 dihydrochloride

CP 31398 dihydrochloride is a p53 stabilizing agent. Stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. Inhibits growth of small human tumor xenografts in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for CP 31398 dihydrochloride

CP 31398 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CP 31398 dihydrochloride

M. Wt 435.39
Formula C22H26N4O.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1217195-61-3
PubChem ID 56972205
Smiles COC(C=C3)=CC=C3/C=C/C2=NC1=CC=CC=C1C(NCCCN(C)C)=N2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CP 31398 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 43.54 100
DMSO 43.54 100

Preparing Stock Solutions for CP 31398 dihydrochloride

The following data is based on the product molecular weight 435.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.3 mL 11.48 mL 22.97 mL
5 mM 0.46 mL 2.3 mL 4.59 mL
10 mM 0.23 mL 1.15 mL 2.3 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets for CP 31398 dihydrochloride

References for CP 31398 dihydrochloride

References are publications that support the biological activity of the product.

Foster et al (1999) Pharmacological rescue of mutant p53 conformation and function. Science 286 2507 PMID: 10617466

Wischhusen et al (2003) CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death. Oncogene 22 8233 PMID: 14614447

Demma et al (2004) CP-31398 restores DNA-binding activity to mutant p53 in vitro but does not affect p53 homologs p63 and p73. J.Biol.Chem. 279 45887 PMID: 15308639

If you know of a relevant reference for CP 31398 dihydrochloride, please let us know.

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2 Citations for CP 31398 dihydrochloride

Citations are publications that use Tocris products. Selected citations for CP 31398 dihydrochloride include:

Grugan et al (2013) A common p53 mutation (R175H) activates c-Met receptor tyrosine kinase to enhance tumor cell invasion. Mol Cell Neurosci 14 853 PMID: 23792586

Roh et al (2011) p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma. Oral Oncol 47 8 PMID: 21109480

Do you know of a great paper that uses CP 31398 dihydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for CP 31398 dihydrochloride


p53 Signaling Pathway

p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.