You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Selective, non-peptide CRF1 receptor antagonist (Ki values are 2.7 and > 10000 nM for CRF1 and CRF2 receptors respectively). Blocks CRF-induced adenylate cyclase activation (Ki = 3.7 nM) and attenuates activation of the HPA axis by CRF. Displays anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant.
Sold for research purposes under agreement from Pfizer Inc.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 400.99. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.99 mL||24.94 mL||49.88 mL|
|2.5 mM||1 mL||4.99 mL||9.98 mL|
|5 mM||0.5 mL||2.49 mL||4.99 mL|
|25 mM||0.1 mL||0.5 mL||1 mL|
References are publications that support the biological activity of the product.
Lundkist et al (1996) A non peptidic cortico. releasing factor receptor antagonist attenuates fever and exhibits anxiolytic activity. Eur.J.Pharmacol. 309 195 PMID: 8874139
Hodgson et al (2007) Comparison of the V1b antagonist, SSR149415, and the CRF1 antagonist, CP-154,526, in rodent models of anxiety and depression. Pharmacol.Biochem.Behav. 86 431 PMID: 17291571
Schulz et al (1996) CP-154,526: a potent and selective nonpeptide antagonist of cortico. releasing factor receptors. Proc.Natl.Acad.Sci.USA 93 10477
If you know of a relevant reference for CP 154526, please let us know.
View Related Products by Product Action
Keywords: CP 154526, CP 154526 supplier, Selective, non-peptide, CRF1, antagonists, Corticotropin-Releasing, Factor1, Receptors, CP154526, Pfizer, 2779, Tocris Bioscience
1 Citation for CP 154526
Citations are publications that use Tocris products. Selected citations for CP 154526 include:
Klampfl et al (2016) CRF-R1 activation in the anterior-dorsal BNST induces maternal neglect in lactating rats via an HPA axis-independent central mechanism. Biochem Biophys Res Commun 64 89 PMID: 26630389
Do you know of a great paper that uses CP 154526 from Tocris? Please let us know.
Reviews for CP 154526
There are currently no reviews for this product. Be the first to review CP 154526 and earn rewards!
Have you used CP 154526?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.