COR 170
Biological Activity
Selective inverse agonist of CB2 receptors (Ki values are 3.8 and >10,000 nM for CB2 and CB1, respectively).
Compound Libraries
COR 170 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 468.63 |
| Formula | C31H36N2O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1048039-15-1 |
| PubChem ID | 25033736 |
| InChI Key | MSJISJDTJJYBFT-UHFFFAOYSA-N |
| Smiles | O=C(C4=CN(CCCCC)C5=C(C=C(C6=CC=CC=C6)C=C5)C4=O)NC12CC(C3)CC(CC3C2)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.37 | 20 | |
| ethanol | 46.86 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 468.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.13 mL | 10.67 mL | 21.34 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.27 mL |
| 10 mM | 0.21 mL | 1.07 mL | 2.13 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Pasquini et al (2008) Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo. J.Med.Chem. 51 5075 PMID: 18680276
Contartese et al (2012) A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury. Pharmacol.Res. 66 555 PMID: 23036353
If you know of a relevant reference for COR 170, please let us know.
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Keywords: COR170 CB2 receptors C2BR inverse agonists selective cannabinoids CB2 Receptors
Citations for COR 170
Citations are publications that use Tocris products.
Currently there are no citations for COR 170. Do you know of a great paper that uses COR 170 from Tocris? If so please let us know.
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