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Conduritol B epoxide
Irreversible glucocerebrosidase (GBA) inhibitor (Ki = 53 μM; IC50 = 4.28 - 9.49 μM). Also inhibitis lysosomal α-glucosidase. Used to generate animal models of Gaucher disease. Accelerates recovery of peripheral nerve injury in mice. Preserves motoneurons and ganglioside distribution at the neuromuscular junction, delays disease onset and improves motor function in a mouse ALS model.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 162.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||6.17 mL||30.84 mL||61.68 mL|
|5 mM||1.23 mL||6.17 mL||12.34 mL|
|10 mM||0.62 mL||3.08 mL||6.17 mL|
|50 mM||0.12 mL||0.62 mL||1.23 mL|
References are publications that support the biological activity of the product.
Witte et al (2010) Ultrasensitive in situ visualization of active glucocerebrosidase molecules. Nat.Chem.Biol. 6 907 PMID: 21079602
Henriques et al (2017) Inhibition of β-glucocerebrosidase activity preserves motor unit integrity in a mouse model of Amyotrophic Lateral Sclerosis. Sci.Rep. 7 5235 PMID: 28701774
Artola et al (2019) Functionalized cyclophellitols are selective glucocerebrosidase inhibitors and induce a bona fide neuropathic Gaucher model in zebrafish. J.Am.Chem.Soc. 141 4214 PMID: 30811188
Kuo et al (2019) In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity-based protein profiling. FEBS J. 286 584 PMID: 30600575
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Keywords: Conduritol B epoxide, Conduritol B epoxide supplier, glucocerebrosidase, acid, lysosomal, beta-glucosidase, glucosylceramide, degradation, inhibitors, inhibits, Gaucher, disease, ALS, amyotrophic, lateral, sclerosis, GBA, Glycosylases, 7056, Tocris Bioscience
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