You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Conduritol B epoxide
Biological Activity for Conduritol B epoxide
Conduritol B epoxide is an irreversible glucocerebrosidase (GBA) inhibitor (Ki = 53 μM; IC50 = 4.28 - 9.49 μM). Also inhibitis lysosomal α-glucosidase. Used to generate animal models of Gaucher disease. Accelerates recovery of peripheral nerve injury in mice. Preserves motoneurons and ganglioside distribution at the neuromuscular junction, delays disease onset and improves motor function in a mouse ALS model.
Technical Data for Conduritol B epoxide
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Conduritol B epoxide
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Conduritol B epoxide
The following data is based on the product molecular weight 162.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||6.17 mL||30.84 mL||61.68 mL|
|5 mM||1.23 mL||6.17 mL||12.34 mL|
|10 mM||0.62 mL||3.08 mL||6.17 mL|
|50 mM||0.12 mL||0.62 mL||1.23 mL|
Product Datasheets for Conduritol B epoxide
References for Conduritol B epoxide
References are publications that support the biological activity of the product.
Witte et al (2010) Ultrasensitive in situ visualization of active glucocerebrosidase molecules. Nat.Chem.Biol. 6 907 PMID: 21079602
Henriques et al (2017) Inhibition of β-glucocerebrosidase activity preserves motor unit integrity in a mouse model of Amyotrophic Lateral Sclerosis. Sci.Rep. 7 5235 PMID: 28701774
Artola et al (2019) Functionalized cyclophellitols are selective glucocerebrosidase inhibitors and induce a bona fide neuropathic Gaucher model in zebrafish. J.Am.Chem.Soc. 141 4214 PMID: 30811188
Kuo et al (2019) In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity-based protein profiling. FEBS J. 286 584 PMID: 30600575
If you know of a relevant reference for Conduritol B epoxide, please let us know.
View Related Products by Product Action
Keywords: Conduritol B epoxide, Conduritol B epoxide supplier, glucocerebrosidase, acid, lysosomal, beta-glucosidase, glucosylceramide, degradation, inhibitors, inhibits, Gaucher, disease, ALS, amyotrophic, lateral, sclerosis, GBA, Glycosylases, 7056, Tocris Bioscience
Citations for Conduritol B epoxide
Citations are publications that use Tocris products.
Currently there are no citations for Conduritol B epoxide. Do you know of a great paper that uses Conduritol B epoxide from Tocris? Please let us know.
Reviews for Conduritol B epoxide
There are currently no reviews for this product. Be the first to review Conduritol B epoxide and earn rewards!
Have you used Conduritol B epoxide?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image