Clindamycin hydrochloride

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Cat.No. 4822 - Clindamycin hydrochloride | C18H33ClN2O5S.HCl | CAS No. 21462-39-5
Description: Antibiotic; inhibits protein synthesis
Chemical Name: Methyl-7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-L-threo-α-D-galacto-octopyranoside hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews (1)
Literature (1)

Biological Activity

Lincosamide antibiotic. Inhibits protein synthesis by binding to the 50S ribosomal subunit and preventing early peptide chain elongation in bacteria.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 461.44
Formula C18H33ClN2O5S.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 21462-39-5
PubChem ID 16051951
InChI Key AUODDLQVRAJAJM-XJQDNNTCSA-N
Smiles CN1[C@H]([C@@](N[C@@]([H])([C@@]2([H])O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O)[C@@H](Cl)C)=O)C[C@@H](CCC)C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.14 100

Preparing Stock Solutions

The following data is based on the product molecular weight 461.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.84 mL 21.67 mL
5 mM 0.43 mL 2.17 mL 4.33 mL
10 mM 0.22 mL 1.08 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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References

References are publications that support the biological activity of the product.

Champney and Tober (2000) Specific inhibition of 50S ribosomal subunit formation in Staphylococcus aureus cells by 16-membered macrolide, lincosamide, and streptogramin B antibiotics. Curr.Microbiol. 41 126 PMID: 10856379

Dhawan and Thadepalli (1982) Clindamycin: a review of fifteen years of experience. Rev.Infect.Dis. 4 1133 PMID: 6818656


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Keywords: Clindamycin hydrochloride, Clindamycin hydrochloride supplier, Lincosamide, antibiotics, bacterial, infections, inhibitors, inhibits, protein, synthesis, 50S, ribosomal, ribosome, bacteria, Antibiotics, 4822, Tocris Bioscience

Citations for Clindamycin hydrochloride

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Reviews for Clindamycin hydrochloride

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Clindamycin and Vancomycin combination therapy study.
By Richard Whiteoak on 11/13/2018
Assay Type: In Vitro
Species: Other

Clindamycin and Vancomycin combination therapy was studied. Susceptibility and time kill studies were carried out on MRSA.

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Literature in this Area

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