Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewTopoisomerase I inhibitor. Forms stable DNA-topoisomerase complexes during DNA replication and induces cell cycle arrest in the G2/M phase. Inhibits growth of a range of cancer cell lines in vitro, as well as of ovarian and leukemia tumors in vivo.
M. Wt | 531.49 |
Formula | C25H27N3O4.H3PO4 |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
PubChem ID | 123773277 |
InChI Key | NWUOSUHZEZPOPE-UQIIZPHYSA-N |
Smiles | O=C1C2=C([C@](CC)(O)C(OC2)=O)C=C3C4=NC5=CC=CC=C5C(CCNC(C)C)=C4CN31.OP(O)(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
water | 10.63 | 20 | |
DMSO | 53.15 | 100 |
The following data is based on the product molecular weight 531.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.88 mL | 9.41 mL | 18.82 mL |
5 mM | 0.38 mL | 1.88 mL | 3.76 mL |
10 mM | 0.19 mL | 0.94 mL | 1.88 mL |
50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
References are publications that support the biological activity of the product.
Kim et al (2015) Anticancer effects of CKD-602 (Camtobell®) via G2/M phase arrest in oral squamous cell carcinoma cell lines. Oncol.Lett. 9 136 PMID: 25435947
Jung et al (2006) The synergism between Belotecan and cisp. in gastric cancer. Cancer Res.Treat. 38 159 PMID: 19771277
If you know of a relevant reference for CKD 602, please let us know.
Keywords: CKD 602, CKD 602 supplier, CKD602, topoisomerase, I, inhibitors, inhibits, cell, cycle, arrest, G2M/phase, Belotecan, Camtobell®, DNA, Topoisomerase, 5125, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for CKD 602. Do you know of a great paper that uses CKD 602 from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review CKD 602 and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.