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Biological Activity for CKD 602
CKD 602 is a topoisomerase I inhibitor. Forms stable DNA-topoisomerase complexes during DNA replication and induces cell cycle arrest in the G2/M phase. Inhibits growth of a range of cancer cell lines in vitro, as well as of ovarian and leukemia tumors in vivo.
Technical Data for CKD 602
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CKD 602
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for CKD 602
The following data is based on the product molecular weight 531.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.88 mL||9.41 mL||18.82 mL|
|5 mM||0.38 mL||1.88 mL||3.76 mL|
|10 mM||0.19 mL||0.94 mL||1.88 mL|
|50 mM||0.04 mL||0.19 mL||0.38 mL|
References for CKD 602
References are publications that support the biological activity of the product.
Kim et al (2015) Anticancer effects of CKD-602 (Camtobell®) via G2/M phase arrest in oral squamous cell carcinoma cell lines. Oncol.Lett. 9 136 PMID: 25435947
Jung et al (2006) The synergism between Belotecan and cisp. in gastric cancer. Cancer Res.Treat. 38 159 PMID: 19771277
If you know of a relevant reference for CKD 602, please let us know.
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Keywords: CKD 602, CKD 602 supplier, CKD602, topoisomerase, I, inhibitors, inhibits, cell, cycle, arrest, G2M/phase, Belotecan, Camtobell®, DNA, Topoisomerase, 5125, Tocris Bioscience
Citations for CKD 602
Citations are publications that use Tocris products.
Currently there are no citations for CKD 602. Do you know of a great paper that uses CKD 602 from Tocris? Please let us know.
Reviews for CKD 602
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.