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Submit ReviewCKD 602
Description: Topoisomerase I inhibitor
Alternative Names: Belotecan, Camtobell®
Chemical Name: (4S)-4-Ethyl-4-hydroxy-11-[2-[(1-methylethyl)amino]ethyl]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione phosphate
Purity: ≥98% (HPLC)
Biological Activity
Topoisomerase I inhibitor. Forms stable DNA-topoisomerase complexes during DNA replication and induces cell cycle arrest in the G2/M phase. Inhibits growth of a range of cancer cell lines in vitro, as well as of ovarian and leukemia tumors in vivo.
Technical Data
| M. Wt | 531.49 |
| Formula | C25H27N3O4.H3PO4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 123773277 |
| InChI Key | NWUOSUHZEZPOPE-UQIIZPHYSA-N |
| Smiles | O=C1C2=C([C@](CC)(O)C(OC2)=O)C=C3C4=NC5=CC=CC=C5C(CCNC(C)C)=C4CN31.OP(O)(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 10.63 | 20 | |
| DMSO | 53.15 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 531.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.88 mL | 9.41 mL | 18.82 mL |
| 5 mM | 0.38 mL | 1.88 mL | 3.76 mL |
| 10 mM | 0.19 mL | 0.94 mL | 1.88 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Kim et al (2015) Anticancer effects of CKD-602 (Camtobell®) via G2/M phase arrest in oral squamous cell carcinoma cell lines. Oncol.Lett. 9 136 PMID: 25435947
Jung et al (2006) The synergism between Belotecan and cisp. in gastric cancer. Cancer Res.Treat. 38 159 PMID: 19771277
If you know of a relevant reference for CKD 602, please let us know.
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Keywords: CKD 602, CKD 602 supplier, CKD602, topoisomerase, I, inhibitors, inhibits, cell, cycle, arrest, G2M/phase, Belotecan, Camtobell®, DNA, Topoisomerase, 5125, Tocris Bioscience
Citations for CKD 602
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.