CK 869

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Cat.No. 4984 - CK 869 | C17H16BrNO3S | CAS No. 388592-44-7
Description: Arp2/3 inhibitor; inhibits actin polymerization
Alternative Names: CK-0157869
Chemical Name: 2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Inhibitor of human and bovine actin-related protein 2/3 (Arp2/3) complex. Inhibits actin polymerization (IC50= 11 μM). Does not inhibit budding or fission yeast Arp2/3 complexes.

Technical Data

M. Wt 394.28
Formula C17H16BrNO3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 388592-44-7
PubChem ID 3574452
InChI Key MVWNPZYLNLATCH-UHFFFAOYSA-N
Smiles O=C1N(C3=CC=C(OC)C=C3OC)C(C2=CC=CC(Br)=C2)SC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.43 100
ethanol 3.94 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 394.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.68 mL 25.36 mL
5 mM 0.51 mL 2.54 mL 5.07 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hetrick et al (2013) Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 20 701 PMID: 23623350

Nolen et al (2009) Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature 460 1031 PMID: 19648907


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View all Actin Inhibitors

Keywords: CK869 CK-0157869 actin-related protein Arp2/3 Arp23 complex actin polymerization inhibitors inhibits CK-0157869 Actin

1 Citation for CK 869

Citations are publications that use Tocris products. Selected citations for CK 869 include:

Bharadwaj (2017) αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin. Nat Commun 8 14348 PMID: 28128308


Do you know of a great paper that uses CK 869 from Tocris? If so please let us know.

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for CK 869

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