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Description: Potent G protein-coupled estrogen receptor (GPER) agonist
Chemical Name: N-[2-Cyclohexyl-4-(1-methylethyl)phenyl]-5-(tetrahydro-2H-pyran-2-yl)-2-furanmethanamine
Purity: ≥98% (HPLC)
Pathways (1)

Biological Activity for CITFA

CITFA is a potent GPER agonist (EC50 = 38.7 nM). It significantly increases axonal and dendritic growth in rat embryonic (E18) hippocampal neurons.

Licensing Information

Sold under licence from Saint Louis University.

Compound Libraries for CITFA

CITFA is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CITFA

M. Wt 381.56
Formula C25H35NO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2379989-52-1
PubChem ID 153360510

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CITFA

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 19.08 50
ethanol 3.82 10

Preparing Stock Solutions for CITFA

The following data is based on the product molecular weight 381.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.24 mL 26.21 mL 52.42 mL
2.5 mM 1.05 mL 5.24 mL 10.48 mL
5 mM 0.52 mL 2.62 mL 5.24 mL
25 mM 0.1 mL 0.52 mL 1.05 mL

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References for CITFA

References are publications that support the biological activity of the product.

DeLeon et al (2022) Novel GPER agonist, CITFA, increases neurite growth in rat embryonic (E18) hippocampal neurons. ACS Chem.Neurosci. 13 1119 PMID: 35353510

If you know of a relevant reference for CITFA, please let us know.

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Keywords: CITFA, CITFA supplier, Potent, GPER, agonists, agonism, estrogen, oestrogen, neurite, growth, Estrogen, (GPER), Receptors, 7811, Tocris Bioscience

Citations for CITFA

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Pathways for CITFA

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.