cis-VZ 185

Pricing Availability   Qty
Description: Negative control for VZ 185 (Cat. No. 6936)
Chemical Name: (2S,4S)-N-(2-((5-(4-(2,6-Dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)piperazin-1-yl)pentyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide
Purity: ≥95% (HPLC)
Literature (2)

Biological Activity for cis-VZ 185

cis-VZ 185 is a negative control for VZ 185 (Cat. No. 6936).

Licensing Information

Sold under licence from the University of Dundee.

Technical Data for cis-VZ 185

M. Wt 995.23
Formula C53H67FN8O8S
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2306193-98-4
Smiles COC1=CC(C2=CN(C(C3=CN=CC=C23)=O)C)=CC(OC)=C1CN4CCN(CC4)CCCCCOC5=C(C=CC(C6=C(N=CS6)C)=C5)CNC([C@@H]7C[C@@H](CN7C([C@H](C(C)(C)C)NC(C8(CC8)F)=O)=O)O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for cis-VZ 185

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 99.52 100

Preparing Stock Solutions for cis-VZ 185

The following data is based on the product molecular weight 995.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1 mL 5.02 mL 10.05 mL
5 mM 0.2 mL 1 mL 2.01 mL
10 mM 0.1 mL 0.5 mL 1 mL
50 mM 0.02 mL 0.1 mL 0.2 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for cis-VZ 185

Certificate of Analysis / Product Datasheet
Select another batch:

References for cis-VZ 185

References are publications that support the biological activity of the product.

Zoppi et al (2019) Iterative design and optimization of initially inactive proteolysis targeting chimeras (PROTACs) identify VZ185 as a potent, fast, and selective Von Hippel-Lindau (VHL) based dual degrader probe of BRD9 and BRD7. J.Med.Chem. 62 699 PMID: 30540463

If you know of a relevant reference for cis-VZ 185, please let us know.

Keywords: cis-VZ 185, cis-VZ 185 supplier, VZ185, potent, selective, VHL, degraders, PROTACs, BRD7, BRD9, negative, controls, cis-VZ185, Bromodomains, Negative, Controls, 6939, Tocris Bioscience

Citations for cis-VZ 185

Citations are publications that use Tocris products.

Currently there are no citations for cis-VZ 185. Do you know of a great paper that uses cis-VZ 185 from Tocris? Please let us know.

Reviews for cis-VZ 185

There are currently no reviews for this product. Be the first to review cis-VZ 185 and earn rewards!

Have you used cis-VZ 185?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Targeted Protein Degradation Research Product Guide

Targeted Protein Degradation Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Ubiquitin-Proteasome System Proteins
  • Assays for Protein Degradation
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia