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Biological Activity for CIQ
CIQ is a subunit-selective potentiator of NMDA receptors containing the GluN2C (formally NR2C) or GluN2D (formally NR2D) subunit. Increases channel opening efficiency and enhances NMDA receptor responses.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Compound Libraries for CIQ
Technical Data for CIQ
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CIQ
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||4.68||10 with sonication|
Preparing Stock Solutions for CIQ
The following data is based on the product molecular weight 467.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.14 mL||10.69 mL||21.37 mL|
|5 mM||0.43 mL||2.14 mL||4.27 mL|
|10 mM||0.21 mL||1.07 mL||2.14 mL|
|50 mM||0.04 mL||0.21 mL||0.43 mL|
References for CIQ
References are publications that support the biological activity of the product.
Mullasseril et al (2010) A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors. Nat.Commun. 1 1 PMID: 20975674
If you know of a relevant reference for CIQ, please let us know.
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Keywords: CIQ, CIQ supplier, NMDA, receptors, potentiators, NR2C, NR2D, subunits, enhances, opening, efficiency, GluN2C, GluN2D, Receptors, 4105, Tocris Bioscience
2 Citations for CIQ
Citations are publications that use Tocris products. Selected citations for CIQ include:
Hedegaard et al (2012) Molecular pharmacology of human NMDA receptors. Neurochem Int 61 601 PMID: 22197913
Kashima and Grueter (2017) Toll-like receptor 4 deficiency alters nucleus accumbens synaptic physiology and drug reward behavior. Proc Natl Acad Sci U S A. 114 8865 PMID: 28760987
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Reviews for CIQ
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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