CIQ

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Cat.No. 4105 - CIQ | C26H26ClNO5 | CAS No. 486427-17-2
Description: Potentiator of NMDA receptors containing NR2C/NR2D
Chemical Name: (3-Chlorophenyl) [3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-2(1H)-isoquinolinyl]methanone
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. Increases channel opening efficiency and enhances NMDA receptor responses.

Compound Libraries

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Technical Data

M. Wt 467.94
Formula C26H26ClNO5
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 486427-17-2
PubChem ID 4231127
InChI Key VYMILMYEENZHAR-UHFFFAOYSA-N
Smiles O=C(C3=CC(Cl)=CC=C3)N2C(COC4=CC=C(OC)C=C4)C1=CC(OC)=C(OC)C=C1CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.79 100
ethanol 4.68 10mM with sonication

Preparing Stock Solutions

The following data is based on the product molecular weight 467.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.14 mL 10.69 mL 21.37 mL
5 mM 0.43 mL 2.14 mL 4.27 mL
10 mM 0.21 mL 1.07 mL 2.14 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Mullasseril et al (2010) A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors. Nat.Commun. 1 1 PMID: 20975674


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Keywords: CIQ, supplier, NMDA, receptors, potentiators, NR2C, NR2D, subunits, enhances, opening, efficiency, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience

1 Citation for CIQ

Citations are publications that use Tocris products. Selected citations for CIQ include:

Hedegaard et al (2012) Molecular pharmacology of human NMDA receptors. Neurochem Int 61 601 PMID: 22197913


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Pathways for CIQ

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