CIQ

Pricing Availability   Qty
Description: Potentiator of NMDA receptors containing GluN2C/GluN2D
Chemical Name: (3-Chlorophenyl) [3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-2(1H)-isoquinolinyl]methanone
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (6)

Biological Activity for CIQ

CIQ is a subunit-selective potentiator of NMDA receptors containing the GluN2C (formally NR2C) or GluN2D (formally NR2D) subunit. Increases channel opening efficiency and enhances NMDA receptor responses.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Compound Libraries for CIQ

CIQ is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CIQ

M. Wt 467.94
Formula C26H26ClNO5
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 486427-17-2
PubChem ID 4231127
InChI Key VYMILMYEENZHAR-UHFFFAOYSA-N
Smiles O=C(C3=CC(Cl)=CC=C3)N2C(COC4=CC=C(OC)C=C4)C1=CC(OC)=C(OC)C=C1CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CIQ

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.79 100
ethanol 4.68 10 with sonication

Preparing Stock Solutions for CIQ

The following data is based on the product molecular weight 467.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.14 mL 10.69 mL 21.37 mL
5 mM 0.43 mL 2.14 mL 4.27 mL
10 mM 0.21 mL 1.07 mL 2.14 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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Product Datasheets for CIQ

Certificate of Analysis / Product Datasheet
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References for CIQ

References are publications that support the biological activity of the product.

Mullasseril et al (2010) A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors. Nat.Commun. 1 1 PMID: 20975674


If you know of a relevant reference for CIQ, please let us know.

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Keywords: CIQ, CIQ supplier, NMDA, receptors, potentiators, NR2C, NR2D, subunits, enhances, opening, efficiency, GluN2C, GluN2D, Receptors, 4105, Tocris Bioscience

2 Citations for CIQ

Citations are publications that use Tocris products. Selected citations for CIQ include:

Kashima and Grueter (2017) Toll-like receptor 4 deficiency alters nucleus accumbens synaptic physiology and drug reward behavior. Proc Natl Acad Sci U S A. 114 8865 PMID: 28760987

Hedegaard et al (2012) Molecular pharmacology of human NMDA receptors. Neurochem Int 61 601 PMID: 22197913


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Reviews for CIQ

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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