Ciglitazone

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Cat.No. 1307 - Ciglitazone | C18H23NO3S | CAS No. 74772-77-3
Description: Selective PPARγ agonist
Chemical Name: 5-[[4-[(1-Methylcyclohexyl)methoxy]phenyl]methyl]-2,4-thiazolidinedione
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (4)

Biological Activity

Selective agonist at PPARγ (peroxisome proliferator-activated receptor γ). Activates PPARγ with an EC50 value of 3 μM in vitro, and is at least 33-fold selective over PPARα and δ. Antihyperglycemic in vivo.

Technical Data

M. Wt 333.44
Formula C18H23NO3S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 74772-77-3
PubChem ID 2987927
InChI Key LOBCDGHHHHGHFA-UHFFFAOYSA-N
Smiles CC1(COC2=CC=C(CC3SC(=O)NC3=O)C=C2)CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 33.34 100

Preparing Stock Solutions

The following data is based on the product molecular weight 333.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3 mL 15 mL 29.99 mL
5 mM 0.6 mL 3 mL 6 mL
10 mM 0.3 mL 1.5 mL 3 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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References

References are publications that support the biological activity of the product.

Jh (1999) Thiazolidinediones - the new Ins enhancers. Clin.Exp.Hypertens. 21 157 PMID: 10052651

Willson et al (1996) The structure-activity relationship between peroxisome proliferator receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J.Med.Chem. 39 665 PMID: 8576907

Xin et al (1999) Peroxisome proliferator-activated receptor γ ligands are potent inhibitors of angiogenesis in vitro and in vivo. J.Biol.Chem. 274 9116 PMID: 10085162


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Keywords: Ciglitazone, Ciglitazone supplier, Selective, PPARγ, PPARgamma, agonists, Peroxisome, Proliferating-activated, Receptors, 1307, Tocris Bioscience

2 Citations for Ciglitazone

Citations are publications that use Tocris products. Selected citations for Ciglitazone include:

Zeitouni et al (2008) Pharmaceutical induction of ApoE secretion by multipotent mesenchymal stromal cells (MSCs). BMC Biotechnol 8 75 PMID: 18823563

Emmans et al (2004) Regulation of cellular processes by PPARgamma ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression. Biochem Soc Trans 32 840 PMID: 15494029


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Literature in this Area

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