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Submit ReviewCiglitazone
Description: Selective PPARγ agonist
Chemical Name: 5-[[4-[(1-Methylcyclohexyl)methoxy]phenyl]methyl]-2,4-thiazolidinedione
Purity: ≥99% (HPLC)
Biological Activity for Ciglitazone
Ciglitazone is a selective agonist at PPARγ (peroxisome proliferator-activated receptor γ). Activates PPARγ with an EC50 value of 3 μM in vitro, and is at least 33-fold selective over PPARα and δ. Antihyperglycemic in vivo.
Technical Data for Ciglitazone
| M. Wt | 333.44 |
| Formula | C18H23NO3S |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 74772-77-3 |
| PubChem ID | 2987927 |
| InChI Key | LOBCDGHHHHGHFA-UHFFFAOYSA-N |
| Smiles | CC1(COC2=CC=C(CC3SC(=O)NC3=O)C=C2)CCCCC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ciglitazone
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. NaOH | 33.34 | 100 |
Preparing Stock Solutions for Ciglitazone
The following data is based on the product molecular weight 333.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3 mL | 15 mL | 29.99 mL |
| 5 mM | 0.6 mL | 3 mL | 6 mL |
| 10 mM | 0.3 mL | 1.5 mL | 3 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.6 mL |
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Product Datasheets for Ciglitazone
References for Ciglitazone
References are publications that support the biological activity of the product.
Jh (1999) Thiazolidinediones - the new Ins enhancers. Clin.Exp.Hypertens. 21 157 PMID: 10052651
Willson et al (1996) The structure-activity relationship between peroxisome proliferator receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J.Med.Chem. 39 665 PMID: 8576907
Xin et al (1999) Peroxisome proliferator-activated receptor γ ligands are potent inhibitors of angiogenesis in vitro and in vivo. J.Biol.Chem. 274 9116 PMID: 10085162
If you know of a relevant reference for Ciglitazone, please let us know.
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Keywords: Ciglitazone, Ciglitazone supplier, Selective, PPARγ, PPARgamma, agonists, Peroxisome, Proliferating-activated, Receptors, 1307, Tocris Bioscience
2 Citations for Ciglitazone
Citations are publications that use Tocris products. Selected citations for Ciglitazone include:
Emmans et al (2004) Regulation of cellular processes by PPARgamma ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression. Biochem Soc Trans 32 840 PMID: 15494029
Zeitouni et al (2008) Pharmaceutical induction of ApoE secretion by multipotent mesenchymal stromal cells (MSCs). BMC Biotechnol 8 75 PMID: 18823563
Do you know of a great paper that uses Ciglitazone from Tocris? Please let us know.
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