Ciglitazone

Pricing Availability Delivery Time Qty
Cat.No. 1307 - Ciglitazone | C18H23NO3S | CAS No. 74772-77-3
Description: Selective PPARγ agonist
Chemical Name: 5-[[4-[(1-Methylcyclohexyl)methoxy]phenyl]methyl]-2,4-thiazolidinedione
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective agonist at PPARγ (peroxisome proliferator-activated receptor γ). Activates PPARγ with an EC50 value of 3 μM in vitro, and is at least 33-fold selective over PPARα and δ. Antihyperglycemic in vivo.

Technical Data

M. Wt 333.44
Formula C18H23NO3S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 74772-77-3
PubChem ID 2987927
InChI Key LOBCDGHHHHGHFA-UHFFFAOYSA-N
Smiles CC1(COC2=CC=C(CC3SC(=O)NC3=O)C=C2)CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 33.34 100
DMSO 33.34 100

Preparing Stock Solutions

The following data is based on the product molecular weight 333.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3 mL 15 mL 29.99 mL
5 mM 0.6 mL 3 mL 6 mL
10 mM 0.3 mL 1.5 mL 3 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Jh (1999) Thiazolidinediones - the new insulin enhancers. Clin.Exp.Hypertens. 21 157 PMID: 10052651

Willson et al (1996) The structure-activity relationship between peroxisome proliferator receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J.Med.Chem. 39 665 PMID: 8576907

Xin et al (1999) Peroxisome proliferator-activated receptor γ ligands are potent inhibitors of angiogenesis in vitro and in vivo. J.Biol.Chem. 274 9116 PMID: 10085162


If you know of a relevant reference for Ciglitazone, please let us know.

View Related Products by Target

View Related Products by Product Action

View all PPARγ Agonists

Keywords: Ciglitazone, supplier, Selective, PPARγ, PPARgamma, agonists, Peroxisome, Proliferating-activated, Receptors, PPARgamma, Receptors, PPARgamma, Receptors, Tocris Bioscience

Citations for Ciglitazone

Citations are publications that use Tocris products.

Currently there are no citations for Ciglitazone. Do you know of a great paper that uses Ciglitazone from Tocris? If so please let us know.

Ciglitazone Reviews

Average Rating:

(Based on 0 Reviews)


1 Star
0%
2 Star
0%
3 Star
0%
4 Star
0%
5 Star
0%

Have you used Ciglitazone?

Submit a review and receive a $25US/€18/£15/$25CAN Amazon gift card if you include an image -$10US/€7/£6/$10CAN Amazon gift card for reviews without an image. Limited to verified customers in USA, Canada and Europe.


Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors