CID 1375606

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Cat.No. 6544 - CID 1375606 | C20H14Cl2N2O2 | CAS No. 313493-80-0
Description: GPR27 agonist
Chemical Name: 2,4-Dichloro-N-(phenylcarbamoyl)phenylbenzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

GPR27 agonist. Promotes recruitment of β-arrestin 2 to chimeric GPR27V2 and wild-type GPR27 in a firefly luciferase complementation assay (pEC50 values are 6.34 and 5.1, respectively).

Technical Data

M. Wt 385.24
Formula C20H14Cl2N2O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 313493-80-0
PubChem ID 1375606
InChI Key PFHDXBXPRBQVAV-UHFFFAOYSA-N
Smiles ClC1=CC(Cl)=C(C(NC2=CC=C(C(NC3=CC=CC=C3)=O)C=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.52 100

Preparing Stock Solutions

The following data is based on the product molecular weight 385.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.6 mL 12.98 mL 25.96 mL
5 mM 0.52 mL 2.6 mL 5.19 mL
10 mM 0.26 mL 1.3 mL 2.6 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Dupuis et al (2017) Activation of the orphan G protein-coupled receptor GPR27 by surrogate ligands promotes β-arrestin 2 recruitment. Mol.Pharmacol. 91 595 PMID: 28314853


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