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Submit ReviewCID 1375606 is a GPR27 agonist. Promotes recruitment of β-arrestin 2 to chimeric GPR27V2 and wild-type GPR27 in a firefly luciferase complementation assay (pEC50 values are 6.34 and 5.1, respectively).
CID 1375606 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
| M. Wt | 385.24 |
| Formula | C20H14Cl2N2O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 313493-80-0 |
| PubChem ID | 1375606 |
| InChI Key | PFHDXBXPRBQVAV-UHFFFAOYSA-N |
| Smiles | ClC1=CC(Cl)=C(C(NC2=CC=C(C(NC3=CC=CC=C3)=O)C=C2)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Dupuis et al (2017) Activation of the orphan G protein-coupled receptor GPR27 by surrogate ligands promotes β-arrestin 2 recruitment. Mol.Pharmacol. 91 595 PMID: 28314853
Keywords: CID 1375606, CID 1375606 supplier, GPR27, agonists, agonism, SREB1, CID11375606, Orphan, 7-TM, Receptors, 6544, Tocris Bioscience
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