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CIA 1 New
Biological Activity for CIA 1
CIA 1 is an inhibitor of the nuclear receptor COUP-TFII (IC50 ranged from 1.2 μM to 7.6 μM, in prostate cancer cell lines). In vitro, CIA 1 inhibits growth of multiple prostate cancer cell lines and suppresses COUP-TFII activity to regulate its target genes. In vivo, CIA 1 reduces tumor growth in prostate cancer xenograft mouse models.
Technical Data for CIA 1
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CIA 1
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for CIA 1
The following data is based on the product molecular weight 365.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||13.67 mL||68.33 mL||136.66 mL|
|1 mM||2.73 mL||13.67 mL||27.33 mL|
|2 mM||1.37 mL||6.83 mL||13.67 mL|
|10 mM||0.27 mL||1.37 mL||2.73 mL|
References for CIA 1
References are publications that support the biological activity of the product.
Wang et al (2020) Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment. Sci.Adv. 6 eaaz8031 PMID: 32494682
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Keywords: CIA 1, CIA 1 supplier, inhibitors, inhibits, COUP, TFII, nuclear, receptor, prostate, cancer, NR2F2, TFCOUP2, Other, Nuclear, Receptors, 7494, Tocris Bioscience
Citations for CIA 1
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Literature in this Area
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