Pricing Availability   Qty
Description: COUP-TFII inhibitor
Chemical Name: N-[2-(3,4-Dimethoxyphenyl)ethyl]-6-methylthieno[2,3-d]pyrimidin-4-amine hydrochloride
Purity: ≥98% (HPLC)

Biological Activity for CIA 1

CIA 1 is an inhibitor of the nuclear receptor COUP-TFII (IC50 ranged from 1.2 μM to 7.6 μM, in prostate cancer cell lines). In vitro, CIA 1 inhibits growth of multiple prostate cancer cell lines and suppresses COUP-TFII activity to regulate its target genes. In vivo, CIA 1 reduces tumor growth in prostate cancer xenograft mouse models.

Technical Data for CIA 1

M. Wt 365.88
Formula C17H19N3O2S.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1049691-47-5
PubChem ID 2974648
Smiles COC1=C(C=C(C=C1)CCNC2=C3C=C(SC3=NC=N2)C)OC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CIA 1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 7.32 20

Preparing Stock Solutions for CIA 1

The following data is based on the product molecular weight 365.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 13.67 mL 68.33 mL 136.66 mL
1 mM 2.73 mL 13.67 mL 27.33 mL
2 mM 1.37 mL 6.83 mL 13.67 mL
10 mM 0.27 mL 1.37 mL 2.73 mL

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References for CIA 1

References are publications that support the biological activity of the product.

Wang et al (2020) Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment. Sci.Adv. 6 eaaz8031 PMID: 32494682

If you know of a relevant reference for CIA 1, please let us know.

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Citations for CIA 1

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