CI 976

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Cat.No. 2227 - CI 976 | C23H39NO4 | CAS No. 114289-47-3
Description: Selective ACAT inhibitor
Chemical Name: 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Selective acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor (IC50 = 0.073 μM). Lowers non-high density lipoprotein (HDL)-cholesterol and increases HDL-cholesterol concentrations in rats with pre-established dyslipidemia. Orally active. Also inhibits Golgi-associated LPL acyltransferase (LPAT) activity (IC50 = 15 μM).

Compound Libraries

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Technical Data

M. Wt 393.57
Formula C23H39NO4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 114289-47-3
PubChem ID 122327
InChI Key WAFNZAURAWBNDZ-UHFFFAOYSA-N
Smiles CCCCCCCCCCC(C)(C)C(=O)NC1=C(OC)C=C(OC)C=C1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 19.68 50
DMSO 39.36 100

Preparing Stock Solutions

The following data is based on the product molecular weight 393.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.7 mL 25.41 mL
5 mM 0.51 mL 2.54 mL 5.08 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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References

References are publications that support the biological activity of the product.

Krause et al (1993) In vivo evidence that the lipid-regulating activity of ACAT inhibitor CI-976 in rats is due to inhibition of both intestinal and liver ACAT. J.Lipid Res. 34 279 PMID: 8429262

Sliskovic and White (1991) Therapeutic potential of ACAT inhibitors as lipid lowering and anti-atherosclerotic agents. TiPS. 12 194

Drecktrah et al (2003) Inhibition of a Golgi complex lysophospholipid acyltransferase induces membrane tubule formation and retrograde trafficking. Mol.Biol.Cell 14 3549


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Keywords: CI 976, CI 976 supplier, Acyl-CoAcholesterol, acyltransferase, ACAT, inhibitors, inhibits, Transferases, CI976, Acyl-CoA:Cholesterol, Acyltransferase, 2227, Tocris Bioscience

2 Citations for CI 976

Citations are publications that use Tocris products. Selected citations for CI 976 include:

Pagliuso et al (2016) Golgi membrane fission requires the CtBP1-S/BARS-induced activation of lysophosphatidic acid acyltransferase δ Nature Communications 7 12148 PMID: 27401954

Schmidt and Brown (2009) Lysophosphatidic acid acyltransferase 3 regulates Golgi complex structure and function. J Cell Biol 186 211 PMID: 19635840


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