CI 1020

Discontinued Product

CI 1020 (Cat. No. 2942) has been withdrawn from sale for commercial reasons.
Description: Highly selective, orally active ETA antagonist
Alternative Names: PD 156707
Chemical Name: 3-(1,3-Benzodioxol-5-yl)-5-hydroxy-5-(4-methoxyphenyl)-4-[(3,4,5-trimethoxyphenyl)methyl]-2(5H)-furanone
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for CI 1020

CI 1020 is a highly selective, orally active, non-peptide endothelin-A receptor (ETA) antagonist (IC50 values are 0.3 and 480 nM for ETA and ETB receptors respectively). Antihypertensive; blocks ET-1-induced pressor responses following oral administration.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for CI 1020

M. Wt 506.5
Formula C28H26O9
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 162256-50-0
PubChem ID 9870830
InChI Key PWIPORDFWDZCJG-UHFFFAOYSA-N
Smiles O=C1C(C2=CC=C(OCO4)C4=C2)=C(CC3=CC(OC)=C(OC)C(OC)=C3)C(O)(C5=CC=C(OC)C=C5)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for CI 1020

Certificate of Analysis / Product Datasheet
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References for CI 1020

References are publications that support the biological activity of the product.

Doherty et al (1995) Discovery of a novel series of orally active non-peptide endothelin-A (ETA) receptor-selective antagonists. J.Med.Chem. 38 1259 PMID: 7731010

Jones et al (1999) The effect of the endothelin ETA receptor antagonist CI-1020 on hypoxic pulmonary vasoconstriction. Eur.J.Pharmacol. 374 367 PMID: 10422781

Coe et al (2002) The endothelin A receptor antagonists PD 156707 (CI-1020) and PD 180988 (CI-1034) reverse the hypoxic pulmonary vasoconstriction in ther perinatal lamb. J.Pharmacol.Exp.Ther. 302 672 PMID: 12130731

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Keywords: CI 1020, CI 1020 supplier, selective, orally, active, ETA, antagonists, Receptors, Endothelin, CI1020, Pfizer, PD156707, PD, 156707, 2942, Tocris Bioscience

Citations for CI 1020

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