CHM 1

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Cat.No. 3868 - CHM 1 | C16H10FNO3 | CAS No. 154554-41-3
Description: Potent antitumor agent; inducer of apoptosis
Chemical Name: 6-(2-Fluorophenyl)-1,3-dioxolo[4,5-g]quinolin-8(5H)-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Inducer of apoptosis; displays potent antitumor ability in human hepatocellular carcinoma. Inhibits tubulin polymerization in vitro and in vivo. Causes cell cycle arrest at G2/M phase by activation of Cdc2 kinase activity. Induces translocation of apoptosis inducing factor (AIF) from the mitochondria to nucleus. Also exhibits vascular targeting activity through upregulation of p53 and induction of death receptor (DR5)-mediated apoptosis in HUVEC cells.

Technical Data

M. Wt 283.25
Formula C16H10FNO3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 154554-41-3
PubChem ID 375860
InChI Key ZMYDAPJHGNEFGQ-UHFFFAOYSA-N
Smiles O=C2C=C(C3=CC=CC=C3F)NC1=CC4=C(OCO4)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 283.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.53 mL 17.65 mL 35.3 mL
5 mM 0.71 mL 3.53 mL 7.06 mL
10 mM 0.35 mL 1.77 mL 3.53 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Wang et al (2008) CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo. Mol.Cancer.Ther. 7 350 PMID: 18281518

Tsai et al (2010) CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein endothelial cells via p53-mediated death receptor 5 up-regulation. J.Biol.Chem. 285 5497 PMID: 20007968


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Keywords: CHM1 apoptosis inducer inhibits tubulin polymerization inhibitors antitumor antivascular cell cycle arrest Apoptosis Inducers

Citations for CHM 1

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for CHM 1

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.

Protocols

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