CHDI 00484077

Pricing Availability   Qty
Description: Potent and selective HDAC class IIa inhibitor
Chemical Name: N-((R)-1-((S)-2-Methylpyrrolidin-1-yl)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity for CHDI 00484077

CHDI 00484077 is a potent and selective class IIa histone deacetylase HDAC inhibitor (IC50 values = 10-30 nM in vivo, 0.01 nM and 0.04 nM in HEK293 and Jurkat cells, respectively). Exhibits 150-fold selectivity for class IIa over class I/IIb HDACs in cells. Orally bioavailable and CNS penetrant.

Licensing Information

Sold under license from CHDI Foundation

Technical Data for CHDI 00484077

M. Wt 382.39
Formula C18H21F3N4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 162675553
InChI Key DBWSFWPXCPNWRZ-NEPJUHHUSA-N
Smiles O=C(C1=CC=C(C=C1)C2=NOC(C(F)(F)F)=N2)N[C@@H](CN3[C@H](CCC3)C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CHDI 00484077

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.24 100 with gentle warming
ethanol 38.24 100 with gentle warming

Preparing Stock Solutions for CHDI 00484077

The following data is based on the product molecular weight 382.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.62 mL 13.08 mL 26.15 mL
5 mM 0.52 mL 2.62 mL 5.23 mL
10 mM 0.26 mL 1.31 mL 2.62 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for CHDI 00484077

References for CHDI 00484077

References are publications that support the biological activity of the product.

Stott et al (2021) Evaluation of 5-(trifluoromethyl)-1,2,4-oxadiazole-based class IIa HDAC inhibitors for Huntington's disease. ACS Med.Chem.Lett 12 380 PMID: 33738065


If you know of a relevant reference for CHDI 00484077, please let us know.

View Related Products by Product Action

View all Class II HDAC Inhibitors

Keywords: CHDI 00484077, CHDI 00484077 supplier, CHDI00484077, potent, selective, inhibitors, inhibits, histone, deacetylase, class, II, IIa, HDAC4, epigenetics, Huntington, Class, HDACs, 7879, Tocris Bioscience

Citations for CHDI 00484077

Citations are publications that use Tocris products.

Currently there are no citations for CHDI 00484077. Do you know of a great paper that uses CHDI 00484077 from Tocris? Please let us know.

Reviews for CHDI 00484077

There are currently no reviews for this product. Be the first to review CHDI 00484077 and earn rewards!

Have you used CHDI 00484077?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Epigenetics in Cancer Poster

Epigenetics in Cancer Poster

This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.

Rheumatoid Arthritis Poster

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.