CHDI 00484077

Pricing Availability   Qty
Description: Potent and selective HDAC class IIa inhibitor
Chemical Name: N-((R)-1-((S)-2-Methylpyrrolidin-1-yl)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity for CHDI 00484077

CHDI 00484077 is a potent and selective class IIa histone deacetylase HDAC inhibitor (IC50 values = 10-30 nM in vivo, 0.01 nM and 0.04 nM in HEK293 and Jurkat cells, respectively). Exhibits 150-fold selectivity for class IIa over class I/IIb HDACs in cells. Orally bioavailable and CNS penetrant.

Licensing Information

Sold under license from CHDI Foundation

Technical Data for CHDI 00484077

M. Wt 382.39
Formula C18H21F3N4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 162675553
Smiles O=C(C1=CC=C(C=C1)C2=NOC(C(F)(F)F)=N2)N[C@@H](CN3[C@H](CCC3)C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CHDI 00484077

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 38.24 100 with gentle warming
ethanol 38.24 100 with gentle warming

Preparing Stock Solutions for CHDI 00484077

The following data is based on the product molecular weight 382.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.62 mL 13.08 mL 26.15 mL
5 mM 0.52 mL 2.62 mL 5.23 mL
10 mM 0.26 mL 1.31 mL 2.62 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets for CHDI 00484077

References for CHDI 00484077

References are publications that support the biological activity of the product.

Stott et al (2021) Evaluation of 5-(trifluoromethyl)-1,2,4-oxadiazole-based class IIa HDAC inhibitors for Huntington's disease. ACS Med.Chem.Lett 12 380 PMID: 33738065

If you know of a relevant reference for CHDI 00484077, please let us know.

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Citations for CHDI 00484077

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

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