CHDI 00390576

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Description: Potent and selective class IIa HDAC inhibitor; brain penetrant
Chemical Name: 2-(2-Fluorophenyl)-N-hydroxy-2-(4-(5-(trifluoromethyl)pyrimidin-2-yl)phenyl)acetamide
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity for CHDI 00390576

CHDI 00390576 is a potent and selective class IIa histone deacetylase (HDAC) inhibitor (IC50 values are 31, 50, 54 and 60 nM for HDAC7, HDAC9, HDAC4 and HDAC5, respectively). Displays >100-fold selectivity for class IIa HDACs over other HDACs. Brain penetrant.

Licensing Information

Sold under license from CHDI Foundation

Technical Data for CHDI 00390576

M. Wt 391.32
Formula C19H13F4N3O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1629729-98-1
PubChem ID 81689842
Smiles ONC(C(C1=C(C=CC=C1)F)C2=CC=C(C3=NC=C(C(F)(F)F)C=N3)C=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CHDI 00390576

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 39.13 100
ethanol 39.13 100

Preparing Stock Solutions for CHDI 00390576

The following data is based on the product molecular weight 391.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.56 mL 12.78 mL 25.55 mL
5 mM 0.51 mL 2.56 mL 5.11 mL
10 mM 0.26 mL 1.28 mL 2.56 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Datasheets for CHDI 00390576

Certificate of Analysis / Product Datasheet
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References for CHDI 00390576

References are publications that support the biological activity of the product.

Luckhurst et al (2019) Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor. Bioorg.Med.Chem.Lett. 29 83 PMID: 30463802

If you know of a relevant reference for CHDI 00390576, please let us know.

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Citations for CHDI 00390576

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

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Epigenetics in Cancer Poster

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