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CGS 9343B is a calmodulin antagonist; inhibits calmodulin-stimulated cAMP phosphodiesterase activity with an IC50 of 3.3 nM. Also prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na+, Ca2+ and K+ currents in PC12 cells and inhibits nAChR.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||5.45||10 with gentle warming|
The following data is based on the product molecular weight 544.61. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||3.67 mL||18.36 mL||36.72 mL|
|2.5 mM||0.73 mL||3.67 mL||7.34 mL|
|5 mM||0.37 mL||1.84 mL||3.67 mL|
|25 mM||0.07 mL||0.37 mL||0.73 mL|
References are publications that support the biological activity of the product.
Norman et al (1987) CGS 9343B, a novel, potent, and selective inhibitor of Calmodulin activity. Mol.Pharmacol. 31 535 PMID: 3033469
Neuhaus and Reber (1992) Inhibition of membrane currents and rises of intracellular Ca2+ in PC12 cells by CGS 9343B, a calmodulin inhibitor. Eur.J.Pharmacol. 226 183 PMID: 1379190
Li et al (2003) Calmodulin regulates the transcriptional activity of estrogen receptors. J.Biol.Chem. 278 1195 PMID: 12419798
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Keywords: CGS 9343B, CGS 9343B supplier, Calmodulin, antagonists, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, CGS9343B, Zaldaride, maleate, 2255, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for CGS 9343B include:
Haag et al (2018) The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea. Cell Rep 24 2418 PMID: 30157434
Hou et al (2015) The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin. Eur J Immunol 13 e1002233 PMID: 26334624
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