CGS 9343B

Pricing Availability   Qty
Description: Calmodulin antagonist
Alternative Names: Zaldaride maleate
Chemical Name: 1,3-Dihydro-1-[1-[(4-methyl-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl)methyl]-4-piperidinyl]-2H-benzimidazol-2-one maleate
Purity: ≥98% (HPLC)
Citations (2)

Biological Activity for CGS 9343B

CGS 9343B is a calmodulin antagonist; inhibits calmodulin-stimulated cAMP phosphodiesterase activity with an IC50 of 3.3 nM. Also prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na+, Ca2+ and K+ currents in PC12 cells and inhibits nAChR.

Technical Data for CGS 9343B

M. Wt 544.61
Formula C26H28N4O2.C4H4O4
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 109826-27-9
PubChem ID 6450522
Smiles OC(=O)\C=C/C(O)=O.CC1(CN2CCC(CC2)N2C(=O)NC3=C2C=CC=C3)OCC2=C(C=CC=C2)N2C=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CGS 9343B

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 27.23 50
ethanol 5.45 10 with gentle warming

Preparing Stock Solutions for CGS 9343B

The following data is based on the product molecular weight 544.61. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.67 mL 18.36 mL 36.72 mL
2.5 mM 0.73 mL 3.67 mL 7.34 mL
5 mM 0.37 mL 1.84 mL 3.67 mL
25 mM 0.07 mL 0.37 mL 0.73 mL

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Product Datasheets for CGS 9343B

Certificate of Analysis / Product Datasheet
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References for CGS 9343B

References are publications that support the biological activity of the product.

Norman et al (1987) CGS 9343B, a novel, potent, and selective inhibitor of Calmodulin activity. Mol.Pharmacol. 31 535 PMID: 3033469

Neuhaus and Reber (1992) Inhibition of membrane currents and rises of intracellular Ca2+ in PC12 cells by CGS 9343B, a calmodulin inhibitor. Eur.J.Pharmacol. 226 183 PMID: 1379190

Li et al (2003) Calmodulin regulates the transcriptional activity of estrogen receptors. J.Biol.Chem. 278 1195 PMID: 12419798

If you know of a relevant reference for CGS 9343B, please let us know.

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Keywords: CGS 9343B, CGS 9343B supplier, Calmodulin, antagonists, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, CGS9343B, Zaldaride, maleate, 2255, Tocris Bioscience

2 Citations for CGS 9343B

Citations are publications that use Tocris products. Selected citations for CGS 9343B include:

Haag et al (2018) The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea. Cell Rep 24 2418 PMID: 30157434

Hou et al (2015) The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin. Eur J Immunol 13 e1002233 PMID: 26334624

Do you know of a great paper that uses CGS 9343B from Tocris? Please let us know.

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