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Submit ReviewCGS 9343B
Description: Calmodulin antagonist
Alternative Names: Zaldaride maleate
Chemical Name: 1,3-Dihydro-1-[1-[(4-methyl-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl)methyl]-4-piperidinyl]-2H-benzimidazol-2-one maleate
Purity: ≥98% (HPLC)
Biological Activity for CGS 9343B
CGS 9343B is a calmodulin antagonist; inhibits calmodulin-stimulated cAMP phosphodiesterase activity with an IC50 of 3.3 nM. Also prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na+, Ca2+ and K+ currents in PC12 cells and inhibits nAChR.
Technical Data for CGS 9343B
| M. Wt | 544.61 |
| Formula | C26H28N4O2.C4H4O4 |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 109826-27-9 |
| PubChem ID | 6450522 |
| InChI Key | NGODOSILXOFQPH-BTJKTKAUSA-N |
| Smiles | OC(=O)\C=C/C(O)=O.CC1(CN2CCC(CC2)N2C(=O)NC3=C2C=CC=C3)OCC2=C(C=CC=C2)N2C=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CGS 9343B
References for CGS 9343B
References are publications that support the biological activity of the product.
Norman et al (1987) CGS 9343B, a novel, potent, and selective inhibitor of Calmodulin activity. Mol.Pharmacol. 31 535 PMID: 3033469
Neuhaus and Reber (1992) Inhibition of membrane currents and rises of intracellular Ca2+ in PC12 cells by CGS 9343B, a calmodulin inhibitor. Eur.J.Pharmacol. 226 183 PMID: 1379190
Li et al (2003) Calmodulin regulates the transcriptional activity of estrogen receptors. J.Biol.Chem. 278 1195 PMID: 12419798
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Keywords: CGS 9343B, CGS 9343B supplier, Calmodulin, antagonists, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, CGS9343B, Zaldaride, maleate, 2255, Tocris Bioscience
2 Citations for CGS 9343B
Citations are publications that use Tocris products. Selected citations for CGS 9343B include:
Haag et al (2018) The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea. Cell Rep 24 2418 PMID: 30157434
Hou et al (2015) The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin. Eur J Immunol 13 e1002233 PMID: 26334624
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