CGS 15943

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Cat.No. 1699 - CGS 15943 | C13H8ClN5O | CAS No. 104615-18-1
Description: Potent adenosine receptor antagonist
Chemical Name: 9-Chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine
Purity: ≥99% (HPLC)
Datasheet
Citations (4)
Reviews (1)
Literature

Biological Activity

Potent adenosine receptor antagonist (Ki values are 3.5, 4.2, 16 and 51 nM for human A1, A2A, A2B and A3 receptors respectively). Orally active in vivo.

Technical Data

M. Wt 285.69
Formula C13H8ClN5O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 104615-18-1
PubChem ID 122070
InChI Key JLPYLHLUHJOPNL-UHFFFAOYSA-N
Smiles NC1=NC2=CC=C(Cl)C=C2C2=NC(=NN12)C1=CC=CO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 1.43 5

Preparing Stock Solutions

The following data is based on the product molecular weight 285.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.5 mL 17.5 mL 35 mL
5 mM 0.7 mL 3.5 mL 7 mL
10 mM 0.35 mL 1.75 mL 3.5 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Ghai et al (1987) Pharmacological characterization of CGS 15943A: a novel nonxanthine adenosine antagonist. J.Pharmacol.Exp.Ther. 242 784 PMID: 3656113

Klotz (2000) Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch.Pharmacol. 362 382 PMID: 11111832

Williams et al (1987) Biochemical characterization of the triazoloquinazoline CGS 15943, a novel, non-xanthine adenosine antagonist. J.Pharmacol.Exp.Ther. 241 415 PMID: 2883298


If you know of a relevant reference for CGS 15943, please let us know.

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Keywords: CGS 15943, supplier, Potent, adenosines, receptor, antagonists, Non-Selective, Receptors, CGS15943, Non-selective, Adenosine, Non-selective, Adenosine, Tocris Bioscience

4 Citations for CGS 15943

Citations are publications that use Tocris products. Selected citations for CGS 15943 include:

Diógenes et al (2014) Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase. Cereb Cortex 24 67 PMID: 22997174

Avanzato et al (2016) Activation of P2X7 and P2Y11 purinergic receptors inhibits migration and normalizes tumor-derived endothelial cells via cAMP signaling Scientific Reports 6 32602 PMID: 27586846

Ilie et al (2012) Adenosine release during seizures attenuates GABAA receptor-mediated depolarization. J Neurosci 32 5321 PMID: 22496577

Stoddart et al (2015) Application of BRET to monitor ligand binding to GPCRs. Nat Methods 12 661 PMID: 26030448


Do you know of a great paper that uses CGS 15943 from Tocris? If so please let us know.

Reviews for CGS 15943

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In vivo and in vitro use of CGS 15943
By Ariel Vitenzon on 01/05/2018
Assay Type: In Vivo
Species: Mouse
Cell Line/Tissue: systemic

This compound was used both in vivo and in vitro. For in vivo experiments we injected the compound systemically into transgenic mice and evaluated the effect of the drug on motor behavior. In vitro we used the drug on slices to evaluate the effect on the physiology of cells.

Drug was dissolved using saline + 0.3% tween 80. (Vortexed for 1 minute and sonicated for 5 min) X3 times.


Literature in this Area

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