CGP 74514 dihydrochloride
Biological Activity
Potent cdk1 inhibitor (IC50 = 25 nM). Reduces Akt phosphorylation and increases mitochondrial damage in leukemia cells in vitro in combination with LY 294002.
Compound Libraries
CGP 74514 dihydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.
Technical Data
M. Wt | 458.82 |
Formula | C19H24ClN7.2HCl |
Storage | Desiccate at RT |
Purity | ≥98% (HPLC) |
PubChem ID | 121513864 |
InChI Key | YFAKNNUHXLCNLG-FZMMWMHASA-N |
Smiles | CCN2C1=NC(N[C@@H]4CCCC[C@@H]4N)=NC(NC3=CC(Cl)=CC=C3)=C1N=C2.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
water | 22.94 | 50 | |
DMSO | 45.88 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 458.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.18 mL | 10.9 mL | 21.8 mL |
5 mM | 0.44 mL | 2.18 mL | 4.36 mL |
10 mM | 0.22 mL | 1.09 mL | 2.18 mL |
50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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References
References are publications that support the biological activity of the product.
Yu et al (2013) The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process. Cancer Res. 63 1822 PMID: 12702569
Furet et al (2000) Structure-based design of potent CDK1 inhibitors derived from olomoucine. J.Comput.Aided Mol.Des. 14 403 PMID: 10896313
If you know of a relevant reference for CGP 74514 dihydrochloride, please let us know.
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.