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CGP 74514 dihydrochloride

Cat. No. 5472 Submit a Review Datasheet / COA / SDS
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Cat.No. 5472 - CGP 74514 dihydrochloride | C19H24ClN7.2HCl
Description: Potent cdk1 inhibitor
Chemical Name: rel-N2-[(1R,2S)-2-Aminocyclohexyl]-N6-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent cdk1 inhibitor (IC50 = 25 nM). Reduces Akt phosphorylation and increases mitochondrial damage in leukemia cells in vitro in combination with LY 294002.

Compound Libraries

CGP 74514 dihydrochloride is also offered as part of the Tocriscreen Kinase Inhibitor Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 458.82
Formula C19H24ClN7.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
PubChem ID 121513864
InChI Key YFAKNNUHXLCNLG-FZMMWMHASA-N
Smiles CCN2C1=NC(N[C@@H]4CCCC[C@@H]4N)=NC(NC3=CC(Cl)=CC=C3)=C1N=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 22.94 50
DMSO 45.88 100

Preparing Stock Solutions

The following data is based on the product molecular weight 458.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.18 mL 10.9 mL 21.8 mL
5 mM 0.44 mL 2.18 mL 4.36 mL
10 mM 0.22 mL 1.09 mL 2.18 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References

References are publications that support the biological activity of the product.

Yu et al (2013) The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process. Cancer Res. 63 1822 PMID: 12702569

Furet et al (2000) Structure-based design of potent CDK1 inhibitors derived from olomoucine. J.Comput.Aided Mol.Des. 14 403 PMID: 10896313

If you know of a relevant reference for CGP 74514 dihydrochloride, please let us know.

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Citations for CGP 74514 dihydrochloride

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