You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
CGH 2466 dihydrochloride
Adenosine A1, A2B and A3 receptor antagonist (IC50 values are 19, 21, and 80 nM respectively). Also inhibits p38 MAPK (IC50 = 187 - 400 nM) and phosphodiesterase type 4D (IC50 = 22 nM). Displays potent anti-inflammatory effects in vitro and in vivo. Potentially useful for asthma and chronic obstructive pulmonary disease (COPD) research.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||3.95||10 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 395.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||25.31 mL||126.54 mL||253.08 mL|
|0.5 mM||5.06 mL||25.31 mL||50.62 mL|
|1 mM||2.53 mL||12.65 mL||25.31 mL|
|5 mM||0.51 mL||2.53 mL||5.06 mL|
References are publications that support the biological activity of the product.
Trifilieff et al (2005) CGH2466, a combined adenosine receptor antagonist, p38 mitogen-activated protein kinase and phosphodiesterase type 4 inhibitor with potent in vitro and in vivo anti-inflammatory activities. Br.J.Pharmacol. 144 1002 PMID: 15685201
If you know of a relevant reference for CGH 2466 dihydrochloride, please let us know.
View Related Products by Product Action
Keywords: CGH 2466 dihydrochloride, CGH 2466 dihydrochloride supplier, A1, A2B, A3, antagonists, inhibitors, inhibits, p38, MAPK, PDE4, Anti-inflammatory, agent, adenosines, receptor, Non-Selective, Receptors, Phosphodiesterases, CGH2466, dihydrochloride, Non-selective, Adenosine, 2344, Tocris Bioscience
1 Citation for CGH 2466 dihydrochloride
Citations are publications that use Tocris products. Selected citations for CGH 2466 dihydrochloride include:
Wakisaka et al (2017) An Adenosine Receptor for Olfaction in Fish. Curr Biol 27 1437 PMID: 28502661
Do you know of a great paper that uses CGH 2466 dihydrochloride from Tocris? Please let us know.
Reviews for CGH 2466 dihydrochloride
There are currently no reviews for this product. Be the first to review CGH 2466 dihydrochloride and earn rewards!
Have you used CGH 2466 dihydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.