CGH 2466 dihydrochloride

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Cat.No. 2344 - CGH 2466 dihydrochloride | C14H9N3SCl2.2HCl | CAS No. 1177618-54-0
Description: A1, A2B and A3 antagonist and inhibitor of p38 MAPK and PDE4
Chemical Name: 4-(3,4-Dichlorophenyl)-5-(4-pyridinyl)-2-thiazolamine dihydrochloride
Purity: ≥99% (HPLC)

Biological Activity

Adenosine A1, A2B and A3 receptor antagonist (IC50 values are 19, 21, and 80 nM respectively). Also inhibits p38 MAPK (IC50 = 187 - 400 nM) and phosphodiesterase type 4D (IC50 = 22 nM). Displays potent anti-inflammatory effects in vitro and in vivo. Potentially useful for asthma and chronic obstructive pulmonary disease (COPD) research.

Technical Data

M. Wt 395.13
Formula C14H9N3SCl2.2HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 1177618-54-0
PubChem ID 16759176
Smiles Cl.Cl.NC1=NC(=C(S1)C1=CC=NC=C1)C1=CC(Cl)=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 3.95 10 with gentle warming
ethanol 1.98 5

Preparing Stock Solutions

The following data is based on the product molecular weight 395.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.31 mL 126.54 mL 253.08 mL
0.5 mM 5.06 mL 25.31 mL 50.62 mL
1 mM 2.53 mL 12.65 mL 25.31 mL
5 mM 0.51 mL 2.53 mL 5.06 mL

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References are publications that support the biological activity of the product.

Trifilieff et al (2005) CGH2466, a combined adenosine receptor antagonist, p38 mitogen-activated protein kinase and phosphodiesterase type 4 inhibitor with potent in vitro and in vivo anti-inflammatory activities. Br.J.Pharmacol. 144 1002 PMID: 15685201

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