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Description: Non-competitive AMPA antagonist
Chemical Name: 1-(4'-Aminophenyl)-3,5-dihydro-7,8-dimethoxy-4H-2,3-benzodiazepin-4-one
Purity: ≥98% (HPLC)
Biological Activity
Novel, selective non-competitive AMPA antagonist. Highly potent, long-acting anticonvulsant.
Technical Data
| M. Wt | 311.34 |
| Formula | C17H17N3O3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 178616-26-7 |
| PubChem ID | 4377504 |
| InChI Key | MJKADKZSYQWGLL-UHFFFAOYSA-N |
| Smiles | COC1=CC2=C(C=C1OC)C(=NNC(=O)C2)C1=CC=C(N)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.13 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 311.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.21 mL | 16.06 mL | 32.12 mL |
| 5 mM | 0.64 mL | 3.21 mL | 6.42 mL |
| 10 mM | 0.32 mL | 1.61 mL | 3.21 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Chimirri et al (1997) 1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists. J.Med.Chem. 40 1258 PMID: 9111300
De Sarro et al (1999) Effects of some AMPA receptor antagonists on the development of tolerance in epilepsy-prone rats and in pentylenetetrazole kindled rats. Eur.J.Pharmacol. 368 149 PMID: 10193651
De Sarro et al (1999) Anticonvulsant activity and plasma level of 2,3-benzodiazepin-4-ones (CFMs) in genetically epilepsy-prone rats. Pharmacol.Biochem.Behav. 63 621 PMID: 10462191
If you know of a relevant reference for CFM-2, please let us know.
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Keywords: CFM-2, CFM-2 supplier, Non-competitive, AMPA, antagonists, Glutamate, Receptors, iGlur, Ionotropic, 1082, Tocris Bioscience
4 Citations for CFM-2
Citations are publications that use Tocris products. Selected citations for CFM-2 include:
Nygaard et al (2015) Melanoma brain colonization involves the emergence of a brain-adaptive phenotype. Proc Natl Acad Sci U S A 1 82 PMID: 25593989
Park et al (2009) Role of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in complete Freund's adjuvant-induced inflammatory pain. Mol Pain 4 67 PMID: 19116032
Rzeski et al (2001) Glutamate antagonists limit tumor growth. J Pharmacol Exp Ther 98 6372 PMID: 11331750
Park et al (2016) Involvement of AMPA Receptor and Its Flip and Flop Isoforms in Retinal Ganglion Cell Death Following Oxygen/Glucose Deprivation. Invest Ophthalmol Vis Sci 57 508 PMID: 26868754
Do you know of a great paper that uses CFM-2 from Tocris? Please let us know.
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