Potent gonadotropin-releasing hormone (GnRH) receptor antagonist (KD = 0.202 nM, IC50 = 1.21 nM). Suppresses production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland, which inhibits ovulation. Exhibits antiproliferative effects and displays efficacy against hormone-sensitive cancers in vivo. Also exhibits anxiolytic and antidepressant activity in vivo.
(Modifications: X-1 = D-2-Nal and N-terminal Ac, Phe-2 = D-(4-Cl-Phe), Ala-3 = D-(3-Pyridyl-Ala), X-6 = D-Cit, Ala-10 = D-Ala and C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1491.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.67 mL||3.35 mL||6.71 mL|
|5 mM||0.13 mL||0.67 mL||1.34 mL|
|10 mM||0.07 mL||0.34 mL||0.67 mL|
|50 mM||0.01 mL||0.07 mL||0.13 mL|
References are publications that support the biological activity of the product.
Beckers et al (1997) Characterization of gonadotropin-releasing hormone analogs based on a sensitive cellular luciferase reporter gene assay. Anal.Biochem. 251 17 PMID: 9300077
Grundker and Emons (2003) Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer. Reprod.Biol.Endocrinol. 1 65 PMID: 14594454
Telegdy et al (2009) Effects of the LHRH antagonist cetrorelix on the brain function in mice. Neuropeptides 43 229 PMID: 19375162
If you know of a relevant reference for Cetrorelix Acetate, please let us know.
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Keywords: Cetrorelix Acetate, Cetrorelix Acetate supplier, Potent, GnRH, antagonists, Peptide, Receptors, Gonadotropin-releasing, Hormone, gonadotrophin, Gonadotrophin-Releasing, 3536, Tocris Bioscience
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