Potassium channel blocker; inhibits the pacemaker current (If) and the hyperpolarization-activated cationic current (Ih). Prevents activation of caspase-3 and neuronal apoptosis in serum- and potassium-deprived cerebellar granule neurons by inactivating GSK-3β.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 168.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.94 mL||29.7 mL||59.4 mL|
|5 mM||1.19 mL||5.94 mL||11.88 mL|
|10 mM||0.59 mL||2.97 mL||5.94 mL|
|50 mM||0.12 mL||0.59 mL||1.19 mL|
References are publications that support the biological activity of the product.
Zhong et al (2007) Cesium chloride protects cerebellar granule neurons from apoptosis induced by low potassium. Int.J.Dev.Neurosci. 25 359 PMID: 17804190
Sharma et al (2012) Magnesium sulfate suppresses L-type calcium currents on the basilar artery smooth muscle cells in rabbits. Neurol.Res. 34 291 PMID: 22450340
Wallick et al (1997) Effects of ionic channel antagonists barium, cesium, and UL-FS-49 on vagal slowing of atrial rate in dogs. Am.J.Physiol. 273 H2155 PMID: 9374748
If you know of a relevant reference for Cesium chloride, please let us know.
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Keywords: Cesium chloride, Cesium chloride supplier, Caesium, chloride, potassium, channel, blockers, If, Ih, currents, neuroprotective, apoptosis, CsCl, Non-selective, /, Other, Potassium, Channels, Apoptosis, HCN, 4739, Tocris Bioscience
Citations for Cesium chloride
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Literature in this Area
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