Cerestat

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Cat.No. 4492 - Cerestat | C20H21N3.HCl | CAS No. 137160-11-3
Description: Potent and noncompetitive NMDA receptor antagonist
Alternative Names: CNS 1102
Chemical Name: N-(3-Ethylphenyl)-N-methyl-N'-1-naphthalenylguanidine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and noncompetitive NMDA receptor antagonist (IC50 = 36 nM). Exhibits >70-fold selectivity for NMDA receptor over σ receptor. Neuroprotective in a rat model of focal ischemia.

Compound Libraries

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Technical Data

M. Wt 339.86
Formula C20H21N3.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 137160-11-3
PubChem ID 60839
InChI Key CKAKVKWRMCAYJD-UHFFFAOYSA-N
Smiles N=C(N(C)C3=CC=CC(CC)=C3)NC1=C2C(C=CC=C2)=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.99 100
water 16.99 50

Preparing Stock Solutions

The following data is based on the product molecular weight 339.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.94 mL 14.71 mL 29.42 mL
5 mM 0.59 mL 2.94 mL 5.88 mL
10 mM 0.29 mL 1.47 mL 2.94 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Reddy et al (1994) Synthesis and structure-activity studies of N,N'-diarylguanidine derivatives. N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive NMDA receptor antagonist. J.Med.Chem. 37 260 PMID: 8295213

Schäbitz et al (2000) The N-methyl-D-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats. Stroke 31 1709 PMID: 10884477


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Keywords: Cerestat, supplier, CNS1102, potent, noncompetitive, NMDA, receptors, antagonists, selective, neuroprotection, neuroprotective, ischemia, stroke, CNS, 1102, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience

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